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Current Rheumatology Reports

, Volume 12, Issue 2, pp 142–148 | Cite as

The Role of Uric Acid and Other Crystals in Osteoarthritis

  • Johannes NowatzkyEmail author
  • Rennie Howard
  • Michael H. Pillinger
  • Svetlana Krasnokutsky
Article

Abstract

Clinicians have long assumed that an association exists between crystal arthropathies and the presence of osteoarthritis (OA). However, studies establishing an independent association between calcium pyrophosphate or uric acid crystal disease and OA are sparse. Even less is known about a possible pathogenic relationship. Whereas some studies suggest that the relationships between crystals and OA may not be incidental and that crystal deposition may contribute to the onset and/or acceleration of OA joint damage, other authors have challenged this assertion. In this review, we provide an overview of past and current research elucidating the role of crystal deposition, including monosodium urate, calcium pyrophosphate, and other crystals, in OA. Given the clinical frequency of gout and that agents exist to modulate serum UA levels, special attention is given to the role of monosodium urate crystals.

Keywords

Crystal arthropathy Osteoarthritis Uric acid Calcium pyrophosphate 

Notes

Disclosure

No potential conflicts of interest relevant to this article were reported.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Johannes Nowatzky
    • 1
    Email author
  • Rennie Howard
    • 1
  • Michael H. Pillinger
    • 1
  • Svetlana Krasnokutsky
    • 1
  1. 1.Department of Medicine, Division of RheumatologyNew York University Hospital for Joint DiseasesNew YorkUSA

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