Current Rheumatology Reports

, Volume 11, Issue 1, pp 15–22 | Cite as

The biomechanics of osteoarthritis: Implications for therapy

  • Joel A. Block
  • Najia Shakoor


The pathophysiology of osteoarthritis (OA) has been extensively studied. However, the basic approach to therapy, which consists of pain relief and maintenance of function, has not changed for decades. At present, there are no nonsurgical methods that clearly interfere with the natural history of OA or provide prolonged pain palliation. Much of OA disease progression is mediated by aberrant biomechanical forces or through pathologic responses to those forces. As understanding of these mechanisms improves, novel therapeutic approaches are being studied that may provide prolonged reductions in loading of OA joints. These new therapies may ultimately be shown to retard disease progression and palliate pain. This article reviews some of these strategies.


Knee Osteoarthritis High Tibial Osteotomy Joint Space Width Medial Knee Knee Adduction Moment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Section of Rheumatology, Rush Medical CollegeRush University Medical CenterChicagoUSA

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