Current Rheumatology Reports

, Volume 8, Issue 1, pp 48–49 | Cite as

Low- dose prednisolone in early rheumatoid arthritis

  • Raj Nair
  • Kenneth G. Saag
Clinical Trials Report

References

  1. 1.
    Hench PS, Kendall EC, Slocumb CH, Polley HF: Effects of cortisone acetate and pituitar y ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions. Arch Med Interna 1950, 85:545–666.PubMedGoogle Scholar
  2. 2.
    Saag K, Kirwan J: Glucocorticoid therapy in rheumatoid arthritis. In Modern Therapeutics in Rheumatic Diseases. Edited by Tsokos GC. Totowa, NJ: Humana Press, Inc.; 2001.Google Scholar
  3. 3.
    Michel BA, Bloch DA, Wolfe F, Fries J: Fractures in rheumatoid arthritis: an evaluation of associated risk factors. J Rheum 1993, 20:1666–1669.PubMedGoogle Scholar
  4. 4.
    Capell HA, Madhok R, Hunter JA, et al.: Lack of radiological and clinical bene.t over two years of low dose prednisolone for rheumatoid arthritis: results of a randomized, controlled trial. Ann Rheum Dis 2004, 63:797–803.PubMedCrossRefGoogle Scholar
  5. 5.
    Kirwan JR: The effect of glucocorticoids on joint destruction in rheumatoid arthritis. The Arthritis and Rheumatism Council Low-dose Glucocorticoid Study Group. N Engl J Med 1995, 333:142–146.PubMedCrossRefGoogle Scholar
  6. 6.
    Rau R, Wassenberg S, Zeidler H: Low-dose prednisolone therapy (LDPT) retards radiographically detectable destruction in early rheumatoid arthritis: preliminary results of a multicenter, randomized, parallel, doubleblind study. Z Rheumatol 2000, 59(suppl 2):90–96.Google Scholar
  7. 7.
    van Everdingenm AA, Jacobs JW, Siewertsz Van Reesema DR, Bijlsma JW: Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, diseasemodifying properties, and side effects: a randomized, double-blind, placebo-controlled clinical trial. Ann Intern Med 2002, 136:1–12.Google Scholar
  8. 8.
    van Everdingenm AA, Siewertsz van Reesema DR, Jacobs JW, Bijlsma JW: Low-dose glucocorticoids in early rheumatoid arthritis: discordant effects on bone mineral density and fractures? Clin Exp Rheumatol 2003, 21:155–160.Google Scholar
  9. 9.
    Boers M, Verhoeven AC, Markusse HM, et al.: Randomised comparison of combined step-down prednisolone, methotrexate, and sulfasalazine with sulfasalazine alone in early rheumatoid arthritis. Lancet 1997, 350:309–318.PubMedCrossRefGoogle Scholar
  10. 10.
    Bijlsma JW, Boers M, Saag KG, Furst DE: Glucocorticoids in the treatment of early and late R A. Ann Rheum Dis 2003, 62:1033–1037.PubMedCrossRefGoogle Scholar
  11. 11.
    Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC: Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblast and osteocytes by glucocorticoids. J Clin Invest 1998, 102:274–282.PubMedCrossRefGoogle Scholar

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© Current Science Inc. 2006

Authors and Affiliations

  • Raj Nair
  • Kenneth G. Saag

There are no affiliations available

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