Current Rheumatology Reports

, Volume 4, Issue 3, pp 252–256 | Cite as

Update on colchicine and its mechanism of action

  • Yair Molad


Colchicine is a unique anti-inflammatory drug with respect to its limited clinical usefulness and its mode of action. Colchicine is mainly indicated for the treatment and prophylaxis of gout and familial Mediterranean fever. Its mode of action includes modulation of chemokine and prostanoid production and inhibition of neutrophil and endothelial cell adhesion molecules by which it interferes with the initiation and amplification of the joint inflammation. This paper discusses its adverse effects and indications.


Colchicine Gout Familial Mediterranean Fever Acute Gout Urate Crystal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Science Inc 2002

Authors and Affiliations

  • Yair Molad
    • 1
  1. 1.Rabin Medical CenterPetah TikvaIsrael

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