An association of silicone-gel breast implant rupture and fibromyalgia
- 94 Downloads
Silicone-gel breast implant rupture is common. Silicone-gel from ruptured implants may escape the scar capsule that forms around breast implants and become “extracapsular silicone.” Our previously published study found that women with extracapsular silicone gel were at higher risk of reporting that they were diagnosed with fibromyalgia. There has been a limited number of studies addressing this association in the literature. Some studies addressing the issue of silicone breast implants and connective tissue disease specifically exclude patients with fibromyalgia from the sample or do not include the syndrome in the analysis. Case series describing fibromyalgia in patients with implants have been published, but many of these papers lack information on extracapsular silicone and are not representative because the patients are typically from referral populations. In addition, most studies do not have control groups of women without implants for comparison or do not distinguish between saline and silicone implants. Additional observational studies of women from nonreferral populations are necessary to validate an association. These studies should provide information on how the rupture is diagnosed, state whether the rupture extended beyond the capsule, and provide an appropriate control group for comparison. The findings from such studies may be important to physicians as they describe potential risks associated with implants to their patients. These findings should also be important for regulatory decision making on silicone-gel breast implants.
KeywordsFibromyalgia Chronic Fatigue Syndrome Breast Implant Symptomatic Woman Functional Somatic Syndrome
Unable to display preview. Download preview PDF.
References and Recommended Reading
- 3.Safety of Silicone Breast Implants. Edited by Bondurant S, Ernster V, Herdman R. Washington, DC: National Academy of Sciences Press; 1999.Google Scholar
- 9.Brown SL, Pennello G, Berg WA, et al.: Silicone gel breast implant rupture, extracapsular silicone, and health status in a population of women. J Rheumatol 2001, 28:996–1003. Describes an association between extracapsular silicone-gel, detected by magnetic resonance imaging, and fibromyalgia in a population of women with breast implants.PubMedGoogle Scholar
- 10.Cronin TD, Gerow FJ: Augmentation mammaplasty: a new "natural feel" prosthesis. Excerpta Medica 1964:41-49.Google Scholar
- 11.The Merck Manual of Diagnosis and Therapy. Edited by Beers MH, Berkow R. Whitehouse Station, NJ: Merck; 1999.Google Scholar
- 14.Brown SL, Middleton MS, Berg WA, et al.: Prevalence of rupture of silicone gel breast implants revealed on MR imaging in a population of women in Birmingham, Alabama. AJR Am J Roentgenol 2000, 175:1057–1064. A study of a nonreferred population of women with breast implants who underwent magnetic resonance examination of their breasts to detect implant rupture.PubMedGoogle Scholar
- 20.Shermis RB, Adler DD, Smith DJJr, Hall JD: Intraductal silicone secondary to breast implant rupture. Breast Dis 1990, 3:17–20.Google Scholar
- 37.Thomas WO III, Harper LL, Wong SW, et al.: Explantation of silicone breast implants. Am J Surg 1997, 5:421–429.Google Scholar