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Current Rheumatology Reports

, Volume 3, Issue 3, pp 191–198 | Cite as

Apoptosis, clearance mechanisms, and the development of systemic lupus erythematosus

  • Jeannine S. Navratil
  • Joseph M. Ahearn
Article

Abstract

Cell death by apoptosis is an integral part of many biologic processes, including embryonic development, T- and B-cell selection, the elimination of potentially autoreactive lymphocytes in the periphery, and maintenance of lymphocyte homeostasis through activation-induced cell death. There is also increasing evidence that apoptosis may maintain immune tolerance and that it may be the process that generates the self antigens responsible for the initial development of autoimmunity. This review discusses some of the biochemical steps involved in the apoptotic process, how potentially immunogenic self antigens are generated during apoptosis, and the mechanisms by which the products of apoptosis are cleared and processed to avoid breaking immune tolerance.

Keywords

Systemic Lupus Erythematosus Apoptotic Cell Immune Tolerance Classical Pathway Congenital Heart Block 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Current Science Inc 2001

Authors and Affiliations

  • Jeannine S. Navratil
  • Joseph M. Ahearn
    • 1
  1. 1.University of Pittsburgh School of MedicineUniversity of Pittsburgh Arthritis InstitutePittsburghUSA

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