Cognitive Genomics: Recent Advances and Current Challenges

  • Joan Fitzgerald
  • Derek W. Morris
  • Gary DonohoeEmail author
Genetic Disorders (F Goes, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Genetic Disorders


Purpose of Review

We review recent progress in uncovering the complex genetic architecture of cognition, arising primarily from genome-wide association studies (GWAS). We explore the genetic correlations between cognitive performance and neuropsychiatric disorders, the genetic and environmental factors associated with age-related cognitive decline, and speculate about the future role of genomics in the understanding of cognitive processes.

Recent Findings

Improvements in genomic methods, and the increasing availability of large datasets via consortia cooperation, have led to a greater understanding of the role played by common and rare variants in the genomics of cognition, the highly polygenic basis of cognitive function and dysfunction, and the multiple biological processes involved.


Recent research has aided in our understanding of the complex biological nature of genomics of cognition. Further development of data banks and techniques to analyze this data hold significant promise for understanding cognitive ability, and for treating cognitively related disability.


Cognition Genomics Schizophrenia Aging GWAS Rare variants 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • Joan Fitzgerald
    • 1
  • Derek W. Morris
    • 1
  • Gary Donohoe
    • 1
    Email author
  1. 1.Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of BiochemistryNational University of Ireland GalwayGalwayIreland

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