Predictors of Transition to Psychosis in Individuals at Clinical High Risk

  • Jean AddingtonEmail author
  • Megan Farris
  • Jacqueline Stowkowy
  • Olga Santesteban-Echarri
  • Paul Metzak
  • Mohammed Shakeel Kalathil
Precision Medicine in Psychiatry (S Kennedy, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Precision Medicine in Psychiatry


Purpose of Review

Current research is examining predictors of the transition to psychosis in youth who are at clinical high risk based on attenuated psychotic symptoms (APS). Determining predictors of the development of psychosis is important for an improved understanding of mechanisms as well as the development of preventative strategies. The purpose is to review the most recent literature identifying predictors of the transition to psychosis in those who are already assessed as being at risk.

Recent Findings

Multidomain models, in particular, integrated models of symptoms, social functioning, and cognition variables, achieve better predictive performance than individual factors. There are many methodological issues; however, several solutions have now been described in the literature.


For youth who already have APS, predicting who may go on to later develop psychosis is possible. Several studies are underway in large consortiums that may overcome some of the methodological concerns and develop improved means of prediction.


Psychosis Prodrome Schizophrenia, predictors Risk factors Clinical high risk 



Preparation of this article was supported by National Institute of Mental Health Grant MH081984 to Jean Addington. Paul Metzak and Olga Santesteban-Echarri are supported by Canadian Institutes of Health Research post-doctoral scholarships.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

All reported studies/experiments with human subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines). This article does not contain any studies with animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jean Addington
    • 1
    Email author
  • Megan Farris
    • 1
  • Jacqueline Stowkowy
    • 1
  • Olga Santesteban-Echarri
    • 1
  • Paul Metzak
    • 1
  • Mohammed Shakeel Kalathil
    • 1
  1. 1.Hotchkiss Brain Institute, Department of PsychiatryUniversity of CalgaryCalgaryCanada

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