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Genetics of Alcoholism

  • Howard J. EdenbergEmail author
  • Joel Gelernter
  • Arpana Agrawal
Genetic Disorders (F Goes, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Genetic Disorders

Abstract

Purpose of Review

We review the search for genetic variants that affect the risk for alcohol dependence and alcohol consumption.

Recent Findings

Variations in genes affecting alcohol metabolism (ADH1B, ALDH2) are protective against both alcohol dependence and excessive consumption, but different variants are found in different populations. There are different patterns of risk variants for alcohol dependence vs. consumption. Variants for alcohol dependence, but not consumption, are associated with risk for other psychiatric illnesses.

Summary

ADH1B and ALDH2 strongly affect both consumption and dependence. Variations in many other genes affect both consumption and dependence—or one or the other of these traits—but individual effect sizes are small. Evidence for other specific genes that affect dependence is not yet strong. Most current knowledge derives from studies of European-ancestry populations, and large studies of carefully phenotyped subjects from different populations are needed to understand the genetic contributions to alcohol consumption and alcohol use disorders.

Keywords

Alcohol dependence Alcoholism Genetics GWAS Alcohol dehydrogenase Drinking 

Notes

Compliance with Ethical Standards

Conflict of Interest

Howard J. Edenberg reports grants from NIH (U01MH109532), unrelated to this study.

Joel Gelernter reports grants from the NIAAA (R01AA026364) and NIH (U01MH109532), unrelated to this study.

Arpana Agrawal reports grants from the NIH (DA23668, DA040411, DA042620, DA046436), unrelated to this study.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Howard J. Edenberg
    • 1
    Email author
  • Joel Gelernter
    • 2
  • Arpana Agrawal
    • 3
  1. 1.Department of Biochemistry and Molecular BiologyIndiana University School of MedicineIndianapolisUSA
  2. 2.Department of Psychiatry, Genetics, and NeuroscienceYale University School of Medicine and VA CT Healthcare CenterWest HavenUSA
  3. 3.Department of PsychiatryWashington University School of MedicineSaint LouisUSA

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