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Pharmacogenetics of Major Depressive Disorder: Top Genes and Pathways Toward Clinical Applications

  • Chiara Fabbri
  • Alessandro SerrettiEmail author
Genetic Disorders (W Berrettini, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Genetic Disorders

Abstract

The pharmacogenetics of antidepressants has been not only a challenging but also frustrating research field since its birth in the 1990s. Indeed, great expectations followed the first evidence of familiar aggregation of antidepressant response. Despite the progress from candidate gene studies to genome-wide association studies (GWAS), results fell out the expectations and they were often inconsistent. Anyway, the cumulative evidence supports the involvement of some genes and molecular pathways in antidepressant efficacy. The best single genes are SLC6A4, HTR2A, BDNF, GNB3, FKBP5, ABCB1, and cytochrome P450 genes (CYP2D6 and CYP2C19). Molecular pathways involved in inflammation and neuroplasticity show the greatest support. The first studies evaluating benefits of genotype-guided antidepressant treatments provided encouraging results and confirmed the relevance of SLC6A4, HTR2A, ABCB1, and cytochrome P450 genes. Further progress in genotyping and data analysis would allow to move forward and complete the understanding of antidepressant pharmacogenetics and its translation into clinical applications.

Keywords

Pharmacogenetics Major depressive disorder Antidepressant Gene Polymorphism Pathway 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Chiara Fabbri declares no conflict of interest.

Alessandro Serretti is or has been a consultant/speaker for Abbott, Astra Zeneca, Clinical Data, Boheringer, Bristol Myers Squibb, Eli Lilly, GlaxoSmithKline, Janssen, Lundbeck, Pfizer, Sanofi, and Servier.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Biomedical and Neuromotor SciencesUniversity of BolognaBolognaItaly

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