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Current Psychiatry Reports

, 17:530 | Cite as

Depression in HIV Infected Patients: a Review

  • Maria Giulia NanniEmail author
  • Rosangela Caruso
  • Alex J. Mitchell
  • Elena Meggiolaro
  • Luigi Grassi
Complex Medical-Psychiatric Issues (MB Riba, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Complex Medical-Psychiatric Issues

Abstract

Depression is the most common neuropsychiatric complication in HIV-infected patients and may occur in all phases of the infection. Accurately, diagnosing major depressive disorder in the context of HIV is an ongoing challenge to clinicians and researchers, being complicated by the complex biological, psychological, and social factors associated with the HIV illness. Evidences exist to support the importance of improving the identification of depressive symptoms and their adequate treatment. Depression has long been recognized as a predictor of negative clinical outcomes in HIV-infected patients, such as reducing medication adherence, quality of life, and treatment outcome, and possibly worsening the progression of the illness and increasing mortality. By analyzing the most relevant studies (MEDLINE, EMBASE, PsycLit, Cochrane Library), the review discusses the epidemiology and the main clinical features of depression in HIV-infected patients, the causal pathways linking depression and HIV infection, the validity of screening tools, and the efficacy of different treatment approaches, including psychosocial interventions, psychopharmacology as well as HIV-specific health psychology health service models.

Keywords

HIV infection Depression Psychosomatic medicine Consultation-liaison psychiatry Psychopharmacology Psychosocial intervention 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Maria Giulia Nanni, Rosangela Caruso, Alex J Mitchell, Elena Meggiolaro, and Luigi Grassi declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Maria Giulia Nanni
    • 1
    • 2
    Email author
  • Rosangela Caruso
    • 1
    • 2
  • Alex J. Mitchell
    • 3
  • Elena Meggiolaro
    • 4
  • Luigi Grassi
    • 1
    • 2
  1. 1.Institute of Psychiatry, Department of Biomedical and Specialty Surgical SciencesUniversity of FerraraFerraraItaly
  2. 2.University Hospital Psychiatry Unit, Program in Psycho-Oncology and Psychiatry in Palliative CareS. Anna University Hospital and Local Health AgenciesFerraraItaly
  3. 3.Department of Psycho-Oncology, Cancer Studies and Molecular MedicineUniversity of LeicesterLeicesterUK
  4. 4.Psycho-Oncology UnitIstituto Scientifico per lo Studio e la Cura dei Tumori (IRST) S.r.l., IRCCSMeldolaItaly

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