Current Psychiatry Reports

, 16:487 | Cite as

Sleep and Substance Use Disorders: An Update

Sleep Disorders (P Gehrman, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Sleep Disorders

Abstract

Substance use disorders (SUD) are common and individuals who suffer from them are prone to relapse. One of the most common consequences of the use of and withdrawal from substances of abuse is sleep disturbance. Substances of abuse affect sleep physiology, including the neurotransmitter systems that regulate the sleep-wake system. Emerging research now highlights an interactive effect between sleep disorders and substance use. New findings in alcohol and sleep research have utilized sophisticated research designs and expanded the scope of EEG and circadian rhythm analyses. Research on marijuana and sleep has progressed with findings on the effects of marijuana withdrawal on objective and subjective measures of sleep. Treatment studies have focused primarily on sleep in alcohol use disorders. Therapies for insomnia in cannabis disorders are needed. Future research is poised to further address mechanisms of sleep disturbance in alcoholics and the effect of medical marijuana on sleep and daytime functioning.

Keywords

Sleep latency (SL) Wake after sleep onset (WASO) Total sleep time (TST) Sleep efficiency (SE; TST/time between “lights out” and “lights on”) Percentages of stages 1 (S1%), 2 (S2%), 3 (S3%), 4 (S4%), Slow wave activity (SWA) Slow wave sleep (SWS%) Rapid eye movement (REM%) Sleep REM latency (REM-L; duration between “sleep onset” and “REM onset”) 

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. 1.
    Mokdad AH, Marks JS, Stroup DF, Gerberding JL. Actual Causes of Death in the United States, 2000. JAMA. 2004;291(10):1238–45. doi:10.1001/jama.291.10.1238.CrossRefPubMedGoogle Scholar
  2. 2.
    NIDA. Understanding Drug Abuse and Addiction. 2012.Google Scholar
  3. 3.
    Cohn T, Foster J, Peters T. Sequential studies of sleep disturbance and quality of life in abstaining alcoholics. Addict Biol. 2003;8:455–62.CrossRefPubMedGoogle Scholar
  4. 4.
    Brower K. Alcohol's effects on sleep in alcoholics. Alcohol Res Health. 2001;25:110–25.PubMedCentralPubMedGoogle Scholar
  5. 5.
    Roehrs T, Roth T. Sleep, sleepiness, sleep disorders and alcohol use and abuse. Sleep Med Rev. 2001;5(4):287–97.CrossRefPubMedGoogle Scholar
  6. 6.
    Bolla K, Lesage S, Gamaldo C, Neubauer D, Funderburk F, Cadet J, et al. Sleep disturbance in heavy marijuana users. Sleep. 2008;31(6):901–8.PubMedCentralPubMedGoogle Scholar
  7. 7.
    Colrain I, Trinder J, Swan G. The impact of smoking cessation on objective and subjective markers of sleep: review, synthesis, and recommendations. Nicotine Tob Res. 2004;6:913–25.CrossRefPubMedGoogle Scholar
  8. 8.
    Roehrs T, Roth T. Caffeine: Sleep and daytime sleepiness. Sleep Med Rev. 2008;12(2):153–62.CrossRefPubMedGoogle Scholar
  9. 9.
    Schierenbeck T, Riemann D, Berger M, Hornyak M. Effect of illicit recreational recreational drug use upon sleep: Cocaine, ecstasy, and marijuana. Sleep Med Rev. 2008;12:381–9.CrossRefPubMedGoogle Scholar
  10. 10.
    Papineau K, Roehrs T, Petrucelli N, Rosenthal L, Roth T. Electrophysiological assessment (The Multiple Sleep Latency Test) of the biphasic effects of ethanol in humans. Alcohol Clin Exp Res. 1998;22(1):231–5.PubMedGoogle Scholar
  11. 11.
    Aldrich M, Shipley J. Alcohol use and periodic limb movements of sleep. Alcohol Clin Exp Res. 1993;17(1):192–6.CrossRefPubMedGoogle Scholar
  12. 12.
    Aldrich MS, Brower KJ, Hall JM. Sleep-disordered breathing in alcoholics. Alcohol Clin Exp Res. 1999;23:134–40.CrossRefPubMedGoogle Scholar
  13. 13.
    Rosenthal L, Roehrs T, Zwyghuizen-Doorenbos A, Plath D, Roth T. Alerting effects of caffeine after normal and restricted sleep. Neuropsychopharmacology. 1991;42(2):103–8.Google Scholar
  14. 14.
    Prosise G, Bonnet M, Berry R, Dickel M. Effects of abstinence from smoking on sleep and daytime sleepiness. Chest. 1994;105(4):1136–41.CrossRefPubMedGoogle Scholar
  15. 15.
    Roehrs T, Papineau K, Rosenthal L, Roth T. Sleepiness and the reinforcing and subjective effects of methylphenidate. Exp Clin Psychopharmacol. 1999;7(2):145–50.CrossRefPubMedGoogle Scholar
  16. 16.
    Johanson C, Roehrs T, Schuh K, Warbasse L. The effects of cocaine on mood and sleep in cocaine-dependent males. Exp Clin Psychopharmacol. 1999;7(4):338–46.CrossRefPubMedGoogle Scholar
  17. 17.
    Walker J, Farney R, Rhondeau S, Boyle K, Valentine K, Cloward T, et al. Chronic opioid use is a risk factor for the development of central sleep apnea and ataxic breathing. J Clin Sleep Med. 2007;3(5):455–61.PubMedCentralPubMedGoogle Scholar
  18. 18.
    Comasco E, Nordquist N, Gokturk C, Aslund C, Hallman J, Oreland L, et al. The clock gene PER2 and sleep problems: Association with alcohol consumption among Swedish adolescents. Ups J Med Sci. 2010;115:41–8.CrossRefPubMedCentralPubMedGoogle Scholar
  19. 19.
    Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura C, Magnone M, et al. The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nat Med. 2005;11(1):35–42.CrossRefPubMedGoogle Scholar
  20. 20.
    Spanagel R, Rosenwasser A, Schumann G, Sarkar D. Alcohol consumption and the body's biological clock. Alcohol Clin Exp Res. 2005;29(8):1550–7.CrossRefPubMedGoogle Scholar
  21. 21.
    Wang X, Mozhui K, Li Z, Mulligan M, Ingels J, Zhou X et al. A promoter polymorphism in the Per3 gene is associated with alcohol and stress response. Transl Psychiatry 2012;2(e73).Google Scholar
  22. 22.•
    Clasadonte J, McIver S, Schmitt L, Halassa M, Haydon P. Chronic sleep restriction disrupts sleep homeostasis and behavioral sensitivity to alcohol by reducing the extracellular accumulation of adenosine. J Neurosci. 2014;34(5):1879–91. This study showed that chronic alcohol intake appears to induce alterations in homeostatic sleep drive in animals.CrossRefPubMedCentralPubMedGoogle Scholar
  23. 23.
    Baimel C, Bartlett S, Chiou L, Lawrence A, Muschamp J, Patkar O, et al. Orexin/hypocretin role in reward: implications for opioid and other addictions. Br J Pharmacol. 2014. doi:10.1111/bph.12639.PubMedGoogle Scholar
  24. 24.
    Cahill E, Salery M, Vanhoutte P, Caboche J. Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse. Front Pharmacol. 2014;4:172. doi:10.3389/fphar.2013.00172.CrossRefPubMedCentralPubMedGoogle Scholar
  25. 25.
    Koob G. Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Curr Top Behav Neurosci. 2013;13:3–30.CrossRefPubMedCentralPubMedGoogle Scholar
  26. 26.
    Matzeu A, Zamora-Martinez E, Martin-Fardon R. The paraventricular nucleus of the thalamus is recruited by both natural rewards and drugs of abuse: recent evidence of a pivotal role for orexin/hypocretin signaling in this thalamic nucleus in drug-seeking behavior. Front Behav Neurosci. 2014;8:117. doi:10.3389/fnbeh.2014.00117. eCollection 2014.CrossRefPubMedCentralPubMedGoogle Scholar
  27. 27.
    Hyman S, Malenka R, Nestler E. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci. 2006;29:565–98.CrossRefPubMedGoogle Scholar
  28. 28.
    Brown R, Basheer R, McKenna J, Strecker R, McCarley R. Control of sleep and wakefulness. Physiol Rev. 2012;92(3):1087–187.CrossRefPubMedCentralPubMedGoogle Scholar
  29. 29.
    Hasler B, Sitnick S, Shaw D, Forbes E. An altered neural response to reward may contribute to alcohol problems among late adolescents with an evening chronotype. Psychiatry Res. 2013;214(3):357–64.CrossRefPubMedGoogle Scholar
  30. 30.
    Johnson EO, Breslau N. Sleep problems and substance use in adolescence. Drug Alcohol Depend. 2001;64(1):1–7.CrossRefPubMedGoogle Scholar
  31. 31.
    Roane BM, Taylor DJ. Adolescent insomnia as a risk factor for early adult depression and substance abuse. Sleep. 2008;31(10):1351–6.PubMedCentralPubMedGoogle Scholar
  32. 32.
    Kenney S, Paves A, Grimaldi E, Labrie J. Sleep Quality and Alcohol Risk in College Students: Examining the Moderating Effects of Drinking Motives. J Am Coll Health. 2014.Google Scholar
  33. 33.
    Popovici I, French M. Binge drinking and sleep problems among young adults. Drug Alcohol Depend. 2013;132(1–2):207–15.CrossRefPubMedCentralPubMedGoogle Scholar
  34. 34.
    Taylor D, Bramoweth A. Patterns and consequences of inadequate sleep in college students: Substance use and motor vehicle accidents. J Adolescents Health. 2010;46:610–2.CrossRefGoogle Scholar
  35. 35.
    Zhabenko O, Krentzman A, Robinson E, Brower K. A longitudinal study of drinking and depression as predictors of insomnia ini alcohol-dependent individuals. Subst Use Misuse. 2013;48(7):495–505.CrossRefPubMedGoogle Scholar
  36. 36.
    Wong M, Brower KJ, Fitzgerald H, Zucker R. Sleep problems in early childhood and early onset of alcohol and other drug use in adolescence. Alcohol: Clin Exp Res. 2004;28(4):578–87.CrossRefGoogle Scholar
  37. 37.
    Wong M, Brower K. The prospective relationship between sleep problems and suicidal behavior in the National Longitudinal Study of Adolescent Health. J Psychiatr Res. 2012;46(7):953–9.CrossRefPubMedCentralPubMedGoogle Scholar
  38. 38.
    Wong M, Brower K, Nigg J, Zucker R. Childhood sleep problems, response inhibition, and alcohol and drug outcomes in adolescence and young adulthood. Alcohol Clin Exp Res. 2010;34(6):1–12.Google Scholar
  39. 39.
    Pasch K, Latimer L, Duncan J, Moe S, Lytle L. Longitudinal Bi-directional relationship between sleep and substance use. J Youth Adolesc. 2012;41:1184–96.CrossRefPubMedCentralPubMedGoogle Scholar
  40. 40.
    Hasler B, Martin C, Wood D, Rosario B, Clark D. A Longitudinal Study of Insomnia and Other Sleep Complaints in Adolescents With and Without Alcohol Use Disorders. Alcohol Clin Exp Res. 2014. doi:10.1111/acer.12474.PubMedGoogle Scholar
  41. 41.
    Dahl R. The impact of inadequate sleep on children’s daytime cognitive function. Semin Pediatr Neurol. 1996;3(1):44–50.CrossRefPubMedGoogle Scholar
  42. 42.
    Dahl R, Lewin D. Pathways to adolescent health: Sleep regulation and behavior. J Adolesc Health. 2002;31:175–84.CrossRefPubMedGoogle Scholar
  43. 43.
    Wills T, Cleary S, Filer M, Shinar O, Mariani J, Spera K. Temperament related to early-onset substance use: test of a developmental model. Prev Sci. 2001;2(3):145–63.CrossRefPubMedGoogle Scholar
  44. 44.
    Hasler B, Dahl R, Holm S, Jakubcak J, Ryan N, Silk J, et al. Weekend-weekday advances in sleep timing are associated with altered reward-related brain function in healthy adolescents. Biol Psychol. 2012;91(3):334–41.CrossRefPubMedCentralPubMedGoogle Scholar
  45. 45.
    Diagnostic and Statistical Manual of Mental Disorders (Fifth ed.). Arlington, VA: American Psychiatric Publishing. 2013.Google Scholar
  46. 46.
    American Academy of Sleep Medicine. International Classification of Sleep Disorders 3rd Edition. Darien. 2014.Google Scholar
  47. 47.
    Grant B, Stinson F, Dawson D, Chou S, Dufour M, Compton W, et al. Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry. 2004;61:807–16.CrossRefPubMedGoogle Scholar
  48. 48.
    Huebner R, Kantor L. Advances in Alcoholism Treatment. Alcohol Res Health. 2011;33(4):295–9.PubMedCentralPubMedGoogle Scholar
  49. 49.
    Arnedt J, Rohsenow D, Almeida A, Hunt S, Gokhale M, Gottlieb D, et al. Sleep following alcohol intoxication in healthy, young adults: effects of sex and family history of alcoholism. Alcohol Clin Exp Res. 2011;35(5):870–8.CrossRefPubMedCentralPubMedGoogle Scholar
  50. 50.
    Pressman M. Alcohol does not increase slow wave sleep. Alcohol Clin Exp Res. 2012;36(8):1474.CrossRefPubMedGoogle Scholar
  51. 51.
    Pressman M, Mahowald M, Schenck C. Alcohol, sleepwalking and violence: lack of reliable scientific evidence. Brain. 2013;136(Pt 2):e229.CrossRefPubMedGoogle Scholar
  52. 52.
    Wittmann M, Paulus M, Roenneberg T. Decreased psychological well-being in late 'chronotypes' is mediated by smoking and alcohol consumption. Subst Use Misuse. 2010;45(1–2):15–30.CrossRefPubMedGoogle Scholar
  53. 53.
    Rupp T, Acebo C, Carskadon M. Evening alcohol suppresses salivary melatonin in young adults. Chronobiol Int. 2007;24(3):463–70.CrossRefPubMedGoogle Scholar
  54. 54.
    Hasler B, Bootzin R, Cousins J, Fridel K, Wenk G. Circadian phase in sleep-disturbed adolescents with a history of substance abuse: A pilot study. Behav Sleep Med. 2008;6:55–73.CrossRefPubMedGoogle Scholar
  55. 55.
    Kuhlwein E, Hauger R, Irwin M. Abnormal nocturnal melatonin secretion and disordered sleep in abstinent alcoholics. Biol Psychiatry. 2003;54(12):1437–43.CrossRefPubMedGoogle Scholar
  56. 56.
    Conroy DA, Hairston IS, Arnedt JT, Hoffmann RF, Armitage R, Brower KJ. Dim light melatonin onset in alcohol-dependent men and women compared with healthy controls. Chronobiol Int. 2012;29(1):35–42. doi:10.3109/07420528.2011.636852.CrossRefPubMedGoogle Scholar
  57. 57.
    Burgess H, Gorenz A, Keshavarzian A, Swanson G. Sleep and melatonin in actively drinking alcoholics. Sleep. 2014;37(Abstract supplement).Google Scholar
  58. 58.
    Johnston L, O’Malley P, Bachman J, Schulenberg J. Monitoring the Future national survey results on drug use, 1975-2006: Volume II, College students and adults ages 19-45. Bethesda: National Institute on Drug Abuse; 2007.Google Scholar
  59. 59.
    Johnston L, O’Malley P, Bachman J, Schulenberg J. Monitoring the Future national survey results on drug use, 1975-2007: Volume I, Secondary school students. Bethesda: National Institute on Drug Abuse; 2008.Google Scholar
  60. 60.
    Johnston L, O'Malley P, Bachman J, Schulenberg J. Monitoring the Future national survey results on drug use, 1975-2012: College students and adults ages 19-50. Ann Arbor: Institute for Social Research The University of Michigan; 2013.Google Scholar
  61. 61.
    Johnston L, O'Malley P, Bachman J, Shulenberg L. Monitoring the Future national survey results on drug use, 1975-2003. National Institute on Drug Abuse. 2004;1: Secondary School Students.Google Scholar
  62. 62.
    Bonn-Miller M, Babson K, Vandrey R. Using cannabis to help you sleep: heightened frequency of medical cannabis use among those with PTSD. Drug Alcohol Depend. 2014;136:162–5.CrossRefPubMedGoogle Scholar
  63. 63.
    Bonn-Miller M, Babson K, Vujanovic A. Sleep problems and PTSD symptoms interact to predict marijuana use coping motives. J Dual Diagn. 2010;6:111–2.CrossRefGoogle Scholar
  64. 64.
    Walsh Z, Callaway R, Belle-Isle L, Caplere R, Kayf R, Lucasd P, et al. Cannabis for therapeutic purposes: Patient characteristics, access, and reasons for use. Int J Drug Policy. 2013;24:511–6.CrossRefPubMedGoogle Scholar
  65. 65.
    Cousins K, DiMascio A. THC as an Hypnotic: An Experimental Study of Three Dose Levels. Psychopharmacologia. 1973;33:355–64.CrossRefGoogle Scholar
  66. 66.
    Nicholson AN, Turner C, Stone BM, Robson PJ. Effects of ∆–9-Tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. J Clin Psychopharmacol. 2004;24(3):305–13.CrossRefPubMedGoogle Scholar
  67. 67.
    Feinberg I, Jones R, Walker JM, Cavness C, March J. Effects of high dosage delta-9-tetrahydrocannabinol on sleep patterns in man. Clin Pharmacol Ther. 1975;17(4):458–66.PubMedGoogle Scholar
  68. 68.
    Gillin JC, Kotin J, Post R, et al. Sleep during one week of administration of ∆-9-tetrahydrocannabinol to psychiatric patients. Sleep Res. 1972;1:44.Google Scholar
  69. 69.
    Barratt ES, Beaver W, White R. The effects of marijuana on human sleep patterns. Biol Psychiatry. 1974;8(1):47–54.PubMedGoogle Scholar
  70. 70.
    Conroy D, Arnedt J, Brower K, Strobbe S, Consens F, Hoffmann R, et al. Perception of sleep in recovering alcohol dependent patients with insomnia: relationship with future drinking. Alcohol Clin Exp Res. 2006;30(12):1986–99.CrossRefGoogle Scholar
  71. 71.
    Colrain I, Turlington S, Baker F. Impact of alcoholism on sleep architecture and EEG power spectra in men and women. Sleep. 2009;32(19):1341–52.PubMedCentralPubMedGoogle Scholar
  72. 72.
    Drummond S, Gillin J, Smith T, DeModena A. The sleep of abstinent pure primary alcoholic patients: natural course and relationship to relapse. Alcohol Clin Exp Res. 1998;22:1796–802.PubMedGoogle Scholar
  73. 73.
    Brower K, Hoffmann R, Conroy D, Arnedt J, Armitage R. Sleep homeostasis in alcohol-dependent, depressed and healthy control men. Eur Arch Psychiatry Clin Neurosci. 2011;261(8):559–66. doi:10.1007/s00406-011-0195-5.CrossRefPubMedCentralPubMedGoogle Scholar
  74. 74.
    Armitage R, Hoffmann R, Conroy DA, Arnedt JT, Brower KJ. Effects of a 3-hour sleep delay on sleep homeostasis in alcohol dependent adults. Sleep. 2012;35(2):273–8. doi:10.5665/sleep.1638.PubMedCentralPubMedGoogle Scholar
  75. 75.
    de Zambotti M, Baker F, Sugarbaker D, Nicholas C, Trinder J, Colrain I. Poor Autonomic Nervous System Functioning During Sleep in Recently Detoxified Alcohol-Dependent Men and Women. Alcohol Clin Exp Res. 2014.Google Scholar
  76. 76.
    Amzica F, Steriade M. The K-complex: its slow (<1-Hz) rhythmicity and relation to delta waves. Neurology. 1997;49:952–9.CrossRefPubMedGoogle Scholar
  77. 77.•
    Colrain I, Crowley K, Nicholas C, Padilla M, Baker F. The impact of alcoholism on sleep evoked Delta frequency responses. Biol Psychiatry. 2009;66(2):177–84. This study showed that alterations in sleep physiology may occur early in abstinence. Google Scholar
  78. 78.•
    Colrain I, Padilla M, Baker F. Partial recovery of alcohol dependence-related deficits in sleep evoked potentials following 12 months of abstinence. Front Neurol. 2012:313. This study showed that alterations in sleep physiology may occur in prolonged abstinence.Google Scholar
  79. 79.
    Cardenas V, Studholme C, Gardzinski S, Durazzo T, Meyerhoff D. Deformation based morphometry of brain changes in alcohol dependence and abstinence. Neuroimage. 2007;34:879–87.CrossRefPubMedCentralPubMedGoogle Scholar
  80. 80.
    O’Neill J, Cardenas V, Meyerhoff D. Effects of abstinence on the brain: quantitative magnetic resonance imaging and magnetic resonance spectroscopic imaging in chronic alcohol abuse. Alcohol Clin Exp Res. 2001;25:1673–82.CrossRefPubMedGoogle Scholar
  81. 81.
    Pfefferbaum A, Sullivan E, Mathalon D, Shear P, Rosenbloom M, Lim K. Longitudinal changes inmagnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcohol Clin Exp Res. 1995;19:1177–91.CrossRefPubMedGoogle Scholar
  82. 82.
    Babson K, Boden M, Bonn-Miller M. The impact of perceived sleep quality and sleep efficiency/duration on cannabis use during a self-guided quit attempt. Addict Behav. 2013;38:2707–13.CrossRefPubMedGoogle Scholar
  83. 83.•
    Babson K, Boden M, Bonn-Miller M. Sleep quality moderates the relation between depression symptoms and problematic cannabis use among medical cannabis users. Am Drug Alcohol Abus. 2013;39(3):211–6. This study was the first to show that poor sleep quality and low mood negatively impacts ability quit marijuana use.CrossRefGoogle Scholar
  84. 84.•
    Babson K, Boden M, Harris A, Stickle T, Bonn-Miller M. Poor sleep quality as a risk factor for lapse following a cannabis quit attempt. J Subst Abus Treat. 2013;44:438–43. This study was the first to show that poor sleep quality negatively impacts ability quit marijuana use.CrossRefGoogle Scholar
  85. 85.
    Budney AJ, Moore BA, Vandrey RG, Hughes JR. The time course and significance of cannabis withdrawal. J Abnorm Psychol. 2003;112(3):393–402.CrossRefPubMedGoogle Scholar
  86. 86.
    Budney A, Hughes J, Moore B, Vandrey R. Review of the validity and significance of cannabis withdrawal syndrome. Am J Psychiatry. 2004;161(11):1967–77.CrossRefPubMedGoogle Scholar
  87. 87.
    Copersino M, Boyd S, Tashkin D, Huestis M, Heishman S, Dermand J. Quitting among non-treatment-seeking marijuana users: reasons and changes in other substance use. Am J Addict. 2006;15(4):297–302.CrossRefPubMedGoogle Scholar
  88. 88.
    Bolla K, Lesage S, Gamaldo C, Neubauer D, Wang N, Funderburk F, et al. Polysomnogram changes in marijuana users who report sleep disturbances during prior abstinence. Sleep Med. 2010;11(9):882–9.CrossRefPubMedCentralPubMedGoogle Scholar
  89. 89.
    Haney M, Hart C, Vosburg S, Comer S, Reed S, Foltin R. Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse. Psychopharmacology. 2008;197(1):157–68.CrossRefPubMedCentralPubMedGoogle Scholar
  90. 90.
    Budney AJ, Hughes JR, Moore BA, Novy PL. Marijuana abstinence effects in marijuana smokers maintained in their home environment. Arch Gen Psychiatry. 2001;58(10):917–24.CrossRefPubMedGoogle Scholar
  91. 91.
    Brower KJ. Insomnia, alcoholism and relapse. Sleep Med Rev. 2003;7(6):523–39.CrossRefPubMedGoogle Scholar
  92. 92.
    Howland R. Gabapentin for Substance Use Disorders: Is it Safe and Appropriate? J Psychosoc Nurs Ment Health Serv. 2014:1-4.Google Scholar
  93. 93.
    Brower K, Kim HM, Strobbe S, Karam-Hage M, Consens F, Zucker R. A randomized double-blind pilot trial of gabapentin versus placebo to treat alcohol dependence and comorbid insomnia. Alcohol Clin Exp Res. 2008;32(8):1–10.Google Scholar
  94. 94.
    Friedmann P, Rose J, Swift R, Stout R, Millman R, Stein M. Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial. Alcohol Clin Exp Res. 2008;32(9):1652–60.CrossRefPubMedCentralPubMedGoogle Scholar
  95. 95.
    Anton R, Myrick H, Wright T, Latham P, Baros A, Waid L, et al. Gabapentin combined with naltrexone for the treatment of alcohol dependence. Am J Psychiatry. 2011;168(7):709–17.CrossRefPubMedCentralPubMedGoogle Scholar
  96. 96.
    Monnelly E, Ciraulo D, Knapp C, LoCastro J, Sepulvda I. Quetiapine for treatment of alcohol dependence. J Clin Psychopharmacol. 2004;24:532–5.CrossRefPubMedGoogle Scholar
  97. 97.
    Chakravorty S, Hanlon A, Kuna S, Ross R, Kampman K, Witte L et al. The Effects of Quetiapine on Sleep in Recovering Alcohol-Dependent Subjects: A Pilot Study. J Clin Psychopharmacol. 2014.Google Scholar
  98. 98.
    Brower K, Conroy D, Kurth M, Stein M. Ramelteon and Improved Insomnia in Alcohol-Dependent Patients: A Case Series. J Clin Sleep Med. 2011;7(3):274–5.PubMedCentralPubMedGoogle Scholar
  99. 99.
    Grosshans M, Mutschler J, Luderer M, Mann K, Kiefer F. Agomelatine is effective in reducing insomnia in abstinent alcohol-dependent patients. Clin Neuropharmacol. 2014;37(1):6–8.PubMedGoogle Scholar
  100. 100.
    Currie SR, Clark S, Hodgins DC, el-Guebaly N. Randomized controlled trial of brief cognitive-behavioural interventions for insomnia in recovering alcohlics. Addiction. 2004;99:1121–32.CrossRefPubMedGoogle Scholar
  101. 101.
    Arnedt JT, Conroy D, Rutt J, Aloia MS, Brower KJ, Armitage R. An open trial of cognitive-behavioral treatment for insomnia comorbid with alcohol dependence. Sleep Med. 2007;8(2):176–80.CrossRefPubMedGoogle Scholar
  102. 102.
    Arnedt J, Conroy D, Armitage R, Brower K. Cognitive-behavioral therapy for insomnia in alcohol dependent patients: a randomized controlled pilot trial. Behav Res Ther. 2011;49(4):227–33.CrossRefPubMedCentralPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.University of Michigan Department of PsychiatryAnn ArborUSA

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