Current Psychiatry Reports

, Volume 14, Issue 1, pp 1–7 | Cite as

Is There a High-Risk Subtype of Depression in Patients with Coronary Heart Disease?



Depression is a risk factor for cardiac morbidity and mortality in patients with coronary heart disease, especially in those with a recent history of acute coronary syndrome. To improve risk stratification and treatment planning, it would be useful to identify the characteristics or subtypes of depression that are associated with the highest risk of cardiac events. This paper reviews the evidence concerning several putative depression subtypes and symptom patterns that may be associated with a high risk of morbidity and mortality in cardiac patients, including single-episode major depressive disorder, depression that emerges after a cardiac event, somatic symptoms of depression, and treatment-resistant depression.


Coronary disease Coronary heart disease Subtype High risk Depression Depressive disorder Major depressive disorder Treatment-resistant depression Myocardial infarction Mortality Myocardial ischemia 



This work was supported in part by grant no. 1R01HL08933601A2 from the National Heart, Lung, and Blood Institute, National Institutes of Health (Bethesda, MD), and support from the Lewis and Jean Sachs Charitable Lead Trust.


No potential conflicts of interest relevant to this article were reported.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Behavioral Medicine Center, Department of PsychiatryWashington University School of MedicineSt. LouisUSA

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