Current Psychiatry Reports

, Volume 13, Issue 6, pp 434–436

Combined Antidepressant Strategies Are Not More Effective Than Vigorous Escitalopram Monotherapy: Results of the CO-MED Study

Clinical Trial Report

References

  1. 1.
    Trivedi MH, Rush AJ, Wisniewski SR, Nierenberg AA, Warden D, Ritz L, et al. STAR*D Study Team. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatr. 2006;163:28–40.PubMedCrossRefGoogle Scholar
  2. 2.
    Kennedy SH, Young AH, Blier P. Strategies to achieve clinical effectiveness: refining existing therapies and pursuing emerging targets. J Affect Disord. 2011;132 Suppl 1:S21–8.PubMedCrossRefGoogle Scholar
  3. 3.
    Thase ME. Antidepressant combinations: widely used, but far from empirically validated. Can J Psychiatr. 2011;56:317–23.Google Scholar
  4. 4.
    Blier P, Gobbi G, Turcotte JE, de Montigny C, Boucher N, Hébert C, et al. Mirtazapine and paroxetine in major depression: a comparison of monotherapy versus their combination from treatment initiation. Eur Neuropsychopharmacol. 2009;19:457–65.PubMedCrossRefGoogle Scholar
  5. 5.
    Blier P, Ward HE, Tremblay P, Laberge L, Hébert C, Bergeron R. Combination of antidepressant medications from treatment initiation for major depressive disorder: a double-blind randomized study. Am J Psychiatr. 2010;167:281–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Coryell W. The search for improved antidepressant strategies: is bigger better? Am J Psychiatr. 2011;168:664–6.PubMedCrossRefGoogle Scholar
  7. 7.
    Nelson JC, Mazure CM, Jatlow PI, Bowers Jr MB, Price LH. Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study. Biol Psychiatr. 2004;55:296–300.CrossRefGoogle Scholar
  8. 8.
    Thase ME. Managing depressive and anxiety disorders with escitalopram. Expert Opin Pharmacother. 2006;7(4):429–40.PubMedCrossRefGoogle Scholar
  9. 9.
    Nelson JC, Papakostas GI. Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials. Am J Psychiatr. 2009;166:980–91.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Philadelphia Veterans Affairs Medical CenterPhiladelphiaUSA
  2. 2.University of Pittsburgh Medical CenterPittsburghUSA
  3. 3.Perelman School of Medicine of the University of PennsylvaniaPhiladelphiaUSA

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