Advertisement

Current Psychiatry Reports

, Volume 13, Issue 2, pp 80–81 | Cite as

Concerns Over Participant Suicides Prematurely Abort a Clinical Trial of Potentially Significant Impact on Public Health: How Will We Make Progress in Timid Times?

  • Joseph F. CubellsEmail author
Clinical Trial Report
  • 51 Downloads

Trial: Topol EJ, Bousser MG, Fox KA, et al.; CRESCENDO Investigators: Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial. Lancet 2010, 376:517–523.

Rating: •Of importance.

Introduction: Obesity, among the most common “preventable” causes of morbidity and premature mortality in developed societies, fundamentally arises from a mismatch between calories consumed (ie, feeding behavior, which in the rich world occurs in the setting of essentially unlimited availability of high-calorie foods) and calories expended (largely a function of how much or little a person uses weight-bearing musculature [ie, exercise behavior]). Thus, it is useful to view obesity and its adverse cardiovascular sequelae as behavioral disorders. The psychopharmacology of obesity is an important topic from the point of view of pharmacologic treatments aimed at influencing feeding behavior [1], as well as the myriad antipsychotic and antidepressant...

Keywords

Suicide Rate Rimonabant Data Safety Monitoring Board Safety Monitoring Board Psychiatric Adverse Event 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Li Z, Maglione M, Tu W, et al.: Meta-analysis: pharmacologic treatment of obesity. Ann Intern Med 2005, 142:532–546.PubMedGoogle Scholar
  2. 2.
    Serretti A, Mandelli L: Antidepressants and body weight: a comprehensive review and meta-analysis. J Clin Psychiatry 2010, 71:1259–1272.PubMedCrossRefGoogle Scholar
  3. 3.
    Tarricone I, Atti AR, Salvatori F, et al.: Weight gain in antipsychotic-naive patients: a review and meta-analysis. Psychol Med 2010, 40:187–200.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Departments of Human Genetics and Psychiatry and Behavioral SciencesEmory University School of MedicineAtlantaUSA

Personalised recommendations