Neuroinflammation and Cognitive Aging
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Cognitive aging describes the changes in mental abilities that occur with increasing age. Although experts disagree on the core underlying processes involved, one factor that links many factors associated with cognitive aging is neuroinflammation. Markers of inflammation are associated directly with deficits in cognitive function and with diseases that are risk factors for cognitive decline. Neuroinflammation is also associated with depression and may account for the complex interaction of depression and cognition in older adults. Interventions that reduce inflammation may improve cognition. Understanding how neuroinflammation affects cognition may provide directions for useful interventions to prevent or treat cognitive decline in older adults.
KeywordsCognition Neuroinflammation Cognitive aging Cognition disorders TNF-α
Dr. Ownby has served on advisory boards and speaker panels for Forest Pharmaceuticals, Janssen, and Pfizer and has received grant support from Janssen.
Papers of particular interest, published recently, have been highlighted as:•• Of major importance
- 1.Park DC: The basic mechanisms accounting for age-related decline in cognitive function. In Cognitive Aging: A Primer. Edited by Park D, Schwarz N. Philadelphia: Taylor & Francis; 2000:3–21.Google Scholar
- 5.•• Lindenberger U, Ghisletta P: Cognitive and sensory declines in old age: gauging the evidence for a common cause. Psychol Aging 2009, 24:1–16. This article provides a useful review of current thinking about possible links between changes in both mental and sensory status with increasing age.CrossRefPubMedGoogle Scholar
- 16.•• Gimeno D, Kivimaki M, Brunner EJ, et al.: Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychol Med 2009, 39:413–423. This article definitively links CRP and IL-6 with depression in a well-known longitudinal study.CrossRefPubMedGoogle Scholar
- 27.Long-Smith CM, Sullivan AM, Nolan YM: The influence of microglia on the pathogenesis of Parkinson’s disease. Prog Neurobiol 2009 Aug 15 (Epub ahead of print).Google Scholar
- 35.Roriz-Filho S, Sa-Roriz TM, Rosset I, et al.: (Pre)diabetes, brain aging, and cognition. Biochim Biophys Acta 2009, 1792:432–443.Google Scholar
- 57.Ownby RL, Loewenstein DA, Kumar M: Anti-inflammatory effects mediate the relation between physical activity and mood in older adults. Paper presented at the Annual Meeting of the International Society of Psychoneuroendocrinology. San Francisco, CA; August 2009.Google Scholar
- 58.•• Cotman CW, Berchtold NC, Christie LA: Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci 2007, 30:464–472. This is an excellent review of the possible links between exercise and cognitive function by way of inflammatory processes.CrossRefPubMedGoogle Scholar
- 61.•• Jaeggi SM, Buschkuehl M, Jonides J, Perrig WJ: Improving fluid intelligence with training on working memory. Proc Natl Acad Sci U S A 2008, 105:6829–6833. This article reports the exciting finding that training in one cognitive domain may have positive effects in another.CrossRefPubMedGoogle Scholar
- 62.•• McNab F, Varrone A, Farde L, et al.: Changes in cortical dopamine D1 receptor binding associated with cognitive training. Science 2009, 323:800–802. This study shows that working memory training may have effects on D 1 -receptor density in areas relevant to working memory function, providing a possible mechanism for the observation by Jaeggi et al. [61••] that working memory training may improve other aspects of cognitive function.CrossRefPubMedGoogle Scholar