Current Psychiatry Reports

, Volume 9, Issue 5, pp 381–387

The future of vaccines in the management of addictive disorders

  • Frank M. Orson
  • Berma M. Kinsey
  • Rana A. K. Singh
  • Yan Wu
  • Tracie Gardner
  • Thomas R. Kosten
Article

Abstract

Conventional substance abuse treatments have had only limited success. As a result, new approaches, including vaccination to block the effects of drugs such as cocaine, nicotine, methamphetamine, and phencyclidine, are in development. Although a number of possible rationales for the effects of antidrug vaccines have been suggested, the most straightforward and intuitive mechanism would involve binding of the drug by antibodies in the blood-stream, thereby blocking entry or reducing the rate of entry of the drug into the central nervous system. The theoretical parameters that would influence vaccine-induced drug pharmacodynamics are presented in this review, along with the current status on vaccine development for nicotine, cocaine, methamphetamine, and phencyclidine.

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Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  • Frank M. Orson
    • 1
  • Berma M. Kinsey
  • Rana A. K. Singh
  • Yan Wu
  • Tracie Gardner
  • Thomas R. Kosten
  1. 1.HoustonUSA

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