Recent advances in the genetics of attention deficit hyperactivity disorder
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In the past few years, interest in the molecular genetics of attention deficit hyperactivity disorder (ADHD) has grown enormously, with many groups searching for susceptibility genes, often through large collaborative efforts facilitated by the International ADHD Genetics Consortium. Association findings for several candidate genes within the dopaminergic system, the DRD4 and DRD5 receptor genes and the dopamine transporter gene, DAT1, have been well replicated, and the first of several ongoing genome linkage scan study results have been published. Current challenges in this field are to identify the actual functional variant(s) in these genes conferring susceptibility and other genetic and environmental risk factors for ADHD.
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References and Recommended Reading
- 2.Meltzer H, Gatward R: Mental Health of Children and Adolescents in GB. London: The Stationery Office; 2000.Google Scholar
- 13.Fisher SE, Francks C, McCracken JT, et al.: A genomewide scan for loci involved in attention-deficit/hyperactivity disorder. Am J Hum Genet 2002, 70:1183–1196. This was the first published genome linkage scan of ADHD, which reported several regions of interest that may harbor ADHD susceptibility genes.PubMedCrossRefGoogle Scholar
- 16.Turic D, Langley K, Mills S, et al.: Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D-aspartate glutamate receptor 2A gene polymorphism with ADHD. Mol Psychiatry 2004, in press.Google Scholar
- 25.Lowe N, Kirley A, Hawi Z, et al.: Joint analysis of DRD5 marker concludes association with ADHD confined to the predominantly inattentive and combined subtypes. Am J Hum Genet 2003, in press.Google Scholar
- 34.Egan MF, Goldberg TE, Kolachana BS, et al.: Effect of COMT val Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 2001, 98:6917–6922. This was one of the first studies to demonstrate a relationship between genotype and neuropsychologic test performance.PubMedCrossRefGoogle Scholar
- 36.Eisenberg J, Mei-Tal G, Steinberg A, et al.: Haplotype relative risk study of cathechol-0-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD): Association of the high-enzyme activity val allele with ADHD impulsivehyperactive phenotype. Am J Med Genet 1999, 88:497–502.PubMedCrossRefGoogle Scholar
- 46.Hamarman S, Fossella J, Ulger C, et al.: Influence of dopamine genes on stimulant response in ADHD children. Scientific Proceedings of the 156th Annual Meeting of the American Psychiatric Association. San Francisco, CA; May 17–22, 2003.Google Scholar
- 47.Castellanos FX, Tannock R: Neuroscience of attention-deficit/ hyperactivity disorder: the search for endophenotypes. Nat Neurosci Rev 2002, 3:617–628.Google Scholar