Psychotic disorder and traumatic brain injury
- 524 Downloads
Traumatic brain injury (TBI) can result in serious and disabling neuropsychiatric disorders, such as cognitive deficits and personality change, as well as severe and chronic psychosis. This review focuses on the relationship between TBI and schizophrenia-like psychosis (SLP) including its epidemiology, diagnostic criteria, clinical presentation, psychopathology, risk factors, and pathophysiology. The relationships between post-traumatic epilepsy and SLP, and brain trauma and schizophrenia, are also discussed. The risk of SLP does increase after TBI. The clinical presentation has considerable overlap with primary schizophrenic disorder, with a prominence of persecutory and other delusions and auditory hallucinations, as well as a lack of negative symptoms. The onset is often gradual, with a subacute or chronic course. More severe and diffuse brain injury, especially of the temporal and frontal lobes, is the most prominent risk factor. Genetic load may also play a role, but presence of epilepsy could be a protective factor. Further large and systematic longitudinal studies are needed.
Unable to display preview. Download preview PDF.
References and Recommended Reading
- 1.Kraus JF, Sorenson SB: Epidemiology. In Neuropsychiatry of Traumatic Injury. Edited by Silver JM, Yudofsky SC, Hales RE. Washington, DC: APPI; 1994:3–41.Google Scholar
- 2.NIH Consensus Development Panel on rehabilitation of persons with traumatic brain injury: Rehabilitation of persons with traumatic brain injury. JAMA 1999, 282:974–983.Google Scholar
- 4.Von Krafft-Ebing R: Ueber die durch Gehirnerschutterung und kopfverletzung hervogerufenen psychischen krankheiten. Eine klinisch-forensische studie. Verlag von Ferdinand enke: Erlngen; 1868.Google Scholar
- 5.Ota Y: Psychiatric studies on civilian head injuries. In The Late Effects of Head Injury. Edited by Walker AE, Caveness WF, Critchley M. Springfield: CC Thomas; 1969:110–119.Google Scholar
- 9.Achte KA, Jarho L, Kyykka T, Vesterinen E: Paranoid disorders following war brain damage: preliminary report. Psychopathology 1991, 45:1–18.Google Scholar
- 11.Davidson, K, Bagley CR: Schizophrenia-like psychosis associated with organic disorders of the central nervous system: a review of the literature. In Current Problems in Neuropsychiatry. Edited by Herrington RN. Ashford, Kent: Headley Brothers; 1969:1–89.Google Scholar
- 14.Cutting J: The phenomenology of acute organic psychosis: comparison with acute schizophrenia. Br J Psychiatry 1987, 15:324–332.Google Scholar
- 16.Miller BL, Benson DF, Cummings JL, Neshkes R: Late-life paraphrenia: an organic delusional syndrome. J Clin Psychiatr 1986, 47:204–207.Google Scholar
- 17.Faraone SV, Tsuang MT, Tsuang DW: Genetics of Mental Disorders: A Guide for Students, Clinicians, and Researchers. New York: Guildford Publications; 1999.Google Scholar
- 24.McGrath J, Murray RM: Risk Factors for Schizophrenia: From Conception to Birth in Schizophrenia. Edited by Hirsch SR, Weinberger DR. Oxford: Blackwell Scientific; 1995:187–205.Google Scholar