Current Psychiatry Reports

, Volume 2, Issue 5, pp 410–415 | Cite as

Update on childhood-onset schizophrenia

  • Judith L. Rapoport
  • Gale Inoff-Germain


Updated findings from the ongoing National Institute of Mental Health Child Psychiatry Branch longitudinal study of childhood-onset schizophrenia (COS) are presented, along with replications from collaborators at other sites. Clinical and neurobiologic continuities of COS with poor-outcome adult-onset schizophrenia suggests that their underlying pathophysiology is the same. However, these early-onset cases appear to have more striking genetic contributions to their etiology. Updated findings involve risk factors (birth complications, cytogenic abnormalities, early language and motor problems, and familial psychopathology), treatment trials, and brain magnetic resonance imaging studies.


Schizophrenia Aripiprazole Acad Child Adolesc Psychiatry Magnetic Resonance Spectroscopic Imaging Onset Schizophrenia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Science Inc 2000

Authors and Affiliations

  • Judith L. Rapoport
    • 1
  • Gale Inoff-Germain
    • 1
  1. 1.Child Psychiatry Branch (Building 10, Room 3N202)National Institute of Mental HealthBethesdaUSA

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