CGRP Antagonists for the Treatment of Chronic Migraines: a Comprehensive Review

  • Ivan UritsEmail author
  • Mark R. Jones
  • Kyle Gress
  • Karina Charipova
  • Jacob Fiocchi
  • Alan D. Kaye
  • Omar Viswanath
Other Pain (A Kaye and N Vadivelu, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Other Pain


Purpose of Review

The purpose of the following review is to summarize the most recent understanding of migraine pathophysiology, as well as of basic and clinical science pharmacologic literature regarding the development of calcitonin gene receptor peptide (CGRP) antagonists as a novel therapeutic modality for the treatment of migraine headaches. A review is provided of erenumab, the first of its class FDA approved CGRP antagonist.

Recent Findings

Despite its high prevalence, the occurrence and treatment of migraine headaches is poorly understood. Erenumab and CGRP antagonists as a whole significantly reduce the average number of migraine days experienced in migraine sufferers.


CGRP antagonists appear to significantly improve treatment outcomes in patients who suffer from episodic and chronic migraines. Erenumab is the first CGRP antagonist to be FDA approved for public use; however, further development of biologics in this class is underway.


Chronic migraines Episodic migraines Calcitonin gene receptor peptide (CGRP) antagonist Erenumab 


Compliance with Ethical Standards

Conflict of Interest

Ivan Urits, Mark R. Jones, Kyle Gress, Karina Charipova, Jacob Fiocchi, and Omar Viswanath declare no conflict of interest. Dr. Kaye is a speaker for Depomed, Inc. and Merck, Inc.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Ivan Urits
    • 1
    Email author
  • Mark R. Jones
    • 1
  • Kyle Gress
    • 2
  • Karina Charipova
    • 2
  • Jacob Fiocchi
    • 3
  • Alan D. Kaye
    • 4
  • Omar Viswanath
    • 5
    • 6
    • 7
  1. 1.Beth Israel Deaconess Medical Center, Department of Anesthesia, Critical Care, and Pain MedicineHarvard Medical SchoolBostonUSA
  2. 2.Georgetown University School of MedicineWashingtonUSA
  3. 3.Creighton University School of Medicine-Phoenix Regional CampusPhoenixUSA
  4. 4.Department of AnesthesiologyLouisiana State University Health Sciences CenterNew OrleansUSA
  5. 5.Valley Anesthesiology and Pain ConsultantsPhoenixUSA
  6. 6.University of Arizona College of Medicine-PhoenixPhoenixUSA
  7. 7.Creighton University School of MedicineOmahaUSA

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