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Episodic Migraine Comorbidities: Avoiding Pitfalls and Taking Therapeutic Opportunities

  • Britany Klenofsky
  • Anna Pace
  • Lauren R. Natbony
  • Huma U. SheikhEmail author
Episodic Migraine (S. Nahas, Section Editor)
  • 222 Downloads
Part of the following topical collections:
  1. Topical Collection on Episodic Migraine

Abstract

Migraine is a common neurologic disorder. This article will discuss a few factors that influence migraine (mostly episodic) and its treatment, such as sleep, obstructive sleep apnea (OSA), obesity, and affective disorders, as well as autoimmune diseases. Practitioners must be aware of these coexisting conditions (comorbidities) as they affect treatment. It is noted in literature that both the quantity (too much or too few hours) and the quality (OSA related) of sleep may worsen migraine frequency. An associated risk factor for OSA, obesity also increases migraine frequency in episodic migraine cases. A bidirectional relationship with migraine along with depression and anxiety is debated in the literature. Retrospective cohort studies are undecided and lack statistical significance, but prospective studies do show promising results on treatment of anxiety and depression as a means of improving migraine control. Finally, we address the topic of autoimmune diseases and migraine. While few studies exist at this time, there are cohort study groups looking into the association between rheumatoid arthritis, hypothyroidism, and antiphospholipid antibody. There is also evidence for the link between migraine and vascular diseases, including coronary and cerebral diseases. We suggest that these comorbid conditions be taken into account and individualized for each patient along with their pharmaceutical regimen. Physicians should seek a multifactorial treatment plan including diet, exercise, and healthy living to reduce migraine frequency.

Keywords

Migraine Sleep Anxiety Depression Obesity 

Notes

Compliance with Ethical Standards

Conflict of Interest

Britany Klenofsky, Anna Pace, Lauren Natbony, and Huma U. Sheikh declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: •• Of major importance

  1. 1.
    •• Manack A, Turkel C, Silberstein S. The evolution of chronic migraine: classification and nomenclature. Headache. 2009;49:1206–13.CrossRefPubMedCentralGoogle Scholar
  2. 2.
    •• Adams AM, Serrano D, Buse DC, et al. The impact of chronic migraine: the Chronic Migraine Epidemiology and Outcomes (CAMEO) Study methods and baseline results. Cephalalgia. 2015;35(7):563–78.CrossRefPubMedCentralGoogle Scholar
  3. 3.
    Blau JN. Resolution of migraine attacks: sleep and the recovery phase. J Neurol Neurosurg Psychiatry. 1982;45:223–6.CrossRefPubMedCentralGoogle Scholar
  4. 4.
    Kelman L, Rains JC. Headache and sleep: examination of sleep patterns and complaints in a large clinical sample of migraineurs. Headache. 2005;45:904–10.CrossRefPubMedCentralGoogle Scholar
  5. 5.
    Fox AW, Davis RL. Migraine chronobiology. Headache. 1998;38:436–41.CrossRefPubMedCentralGoogle Scholar
  6. 6.
    Dodick DW, Eross EJ, Parish JM, Silber M. Clinical, anatomical, and physiologic relationship between sleep and headache. Headache. 2003;43(3):282–92.CrossRefPubMedCentralGoogle Scholar
  7. 7.
    Barbanti P, Fabbrini G, Aurilia C, Vanacore N, Cruccu G. A case-control study on excessive daytime sleepiness in episodic migraine. Cephalalgia. 2007;27:1115–9.CrossRefPubMedCentralGoogle Scholar
  8. 8.
    Sancisi E, Cevoli S, Vignatelli L, Nicodemo M, Pierangeli G, Zanigni S, et al. Increased prevalence of sleep disorders in chronic headache: a case-control study. Headache. 2010;50(9):1464–72.CrossRefPubMedCentralGoogle Scholar
  9. 9.
    Johnson KG, Zimeba AM, Garb JL. Improvement in headaches with continuous positive airway pressure for obstructive sleep apnea: a retrospective analysis. Headache. 2013;53(2):333–43.CrossRefPubMedCentralGoogle Scholar
  10. 10.
    Calhoun AH, Ford S. Behavioral sleep modification may revert transformed migraine to episodic migraine. Headache. 2007;47:1178–83.CrossRefPubMedCentralGoogle Scholar
  11. 11.
    Rains JC, Poceta JS. Headache and sleep disorders: review and clinical implications for headache management. Headache. 2006;46(9):1344–63.CrossRefPubMedCentralGoogle Scholar
  12. 12.
    Winter AC, Schürks M, Berger K, Buring JE, Gaziano JM, Kurth T. Migraine and restless legs syndrome in men. Cephalalgia. 2013;33:130–5.CrossRefPubMedCentralGoogle Scholar
  13. 13.
    Kanki R, Takeshima T. Restless legs syndrome as a comorbidity of migraine. Cephalalgia. 2011;31(Suppl 1):160.Google Scholar
  14. 14.
    Lin G-Y, Lin Y-K, Lee J-T, Lee MS, Lin CC, Tsai CK, et al. Prevalence of restless legs syndrome in migraine patients with and without aura: a cross-sectional, case-controlled study. J Headache Pain. 2016;17(1):97.CrossRefPubMedCentralGoogle Scholar
  15. 15.
    Cannon PR, Larner AJ. Migraine and restless legs syndrome: is there an association? J Headache Pain. 2011;12(4):405–9.CrossRefPubMedCentralGoogle Scholar
  16. 16.
    Cologno D, Cicarelli G, Petretta V, d’Onofrio F, Bussone G. High prevalence of dopaminergic premonitory symptoms in migraine patients with restless legs syndrome: a pathogenetic link? Neurol Sci. 2008;29(Suppl 1):S166–8.CrossRefPubMedCentralGoogle Scholar
  17. 17.
    WHO. Obesity-preventing and managing the global epidemic. report of WHO Consultation on Obesity. Geneva: World Health Organization; 1997.Google Scholar
  18. 18.
    Evans RW, Williams MA, Rapoport AM, Peterlin BL. The association of obesity with episodic and chronic migraine. Headache. 2012;52(4):663–71.CrossRefPubMedCentralGoogle Scholar
  19. 19.
    Vo M, Ainalem A, Qiu C, Peterlin BL, Aurora SK, Williams MA. Body mass index and adult weight gain among reproductive age women with migraine. Headache. 2011;51:559–69.CrossRefPubMedCentralGoogle Scholar
  20. 20.
    Bigal ME, Lipton RB. Obesity is a risk factor for transformed migraine but not chronic tension-type headache. Neurology. 2006;67:252–7.CrossRefPubMedCentralGoogle Scholar
  21. 21.
    Robberstad L, Dyb G, Hagen K, Stovner LJ, Holmen TL, Zwart JA. An unfavorable lifestyle and recurrent headaches among adolescents: the HUNT study. Neurology. 2010;75:712–7.CrossRefPubMedCentralGoogle Scholar
  22. 22.
    Varkey E, Cider A, Carlsson J, Linde M. Exercise as migraine prophylaxis: a randomized study using relaxation and topiramate as controls. Cephalalgia. 2011;31:1428–38.CrossRefPubMedCentralGoogle Scholar
  23. 23.
    Young WB, Rozen TD. Preventive treatment of migraine: effect on weight. Cephalalgia. 2005;25:1–11.CrossRefPubMedCentralGoogle Scholar
  24. 24.
    Peterlin BL. Bariatric surgery in obese migraineurs: mounting evidence but important questions remain. Cephalalgia. 2011;31:1333–5.CrossRefPubMedCentralGoogle Scholar
  25. 25.
    Chu H, et al. Associations between depression/anxiety and headache frequency in migraineurs: a cross-sectional study. Headache. 2018;58(3):407–15.CrossRefPubMedCentralGoogle Scholar
  26. 26.
    Zarcone D, Corbetta S. Shared mechanisms of epilepsy, migraine and affective disorders. Neurol Sci. 2017;38:S73–6.CrossRefGoogle Scholar
  27. 27.
    Dikmen P, Yavuz B, Aydinlar E. The relationships between migraine, depression and anxiety and sleep disturbances. Acta Neurol Belg. 2015;115(2):117–22.CrossRefGoogle Scholar
  28. 28.
    Smitherman T, Kolivas E, Bailey J. Panic disorder and migraine: comorbidity, mechanisms, and clinical implications. Headache. 2013;53(1):23–45.CrossRefPubMedCentralGoogle Scholar
  29. 29.
    Novic A, Kolves K, O’Dwyer S, De Leo D. Migraine and suicidal behaviors a systematic literature review. Clin J Pain. 2016;32:351–64.CrossRefPubMedCentralGoogle Scholar
  30. 30.
    Frediani F, Villani V. Migraine and depression. Neurol Sci. 2007;28(Suppl 2):S161–5.CrossRefPubMedCentralGoogle Scholar
  31. 31.
    Merikangas K. Psychopathology and headache syndromes in the community. Headache. 1994;34:S17–26.CrossRefPubMedCentralGoogle Scholar
  32. 32.
    Juang K, Yang C-Y. Psychiatric comorbidity of chronic daily headache: focus on traumatic experiences in childhood, post-traumatic stress disorder and suicidality. Curr Pain Headache Rep. 2014;18:405.CrossRefPubMedCentralGoogle Scholar
  33. 33.
    Palacios-Cena M, et al. Women with chronic and episodic exhibit similar widespread pressure sensitivity. Pain Med. 2016;17(11):2127–33.CrossRefPubMedCentralGoogle Scholar
  34. 34.
    Mohseni N, Togha M, Arzaghi SM, Nekooie S, Tafti MF, Fatehi F. Personality trats and anxiety and depressive disorders in patients with medication-overuse headaches versus episodic migraine. Prim Care Companion CNS Disord. 2017;14:19(6).Google Scholar
  35. 35.
    Ruscheweyh R, Müller M, Blum B, Straube A. Correlation of headache frequency and psychosocial impairment in migraine: a cross-sectional study. Headache. 2014;54(5):861–71.CrossRefPubMedCentralGoogle Scholar
  36. 36.
    Leo R, Singh J. Migraine headache and bipolar disorder comorbidity: a systematic review of the literature and clinical implications. Scand J Pain. 2016;11:136–45.CrossRefPubMedCentralGoogle Scholar
  37. 37.
    Huddleston C, Martin L, Woods K, Dindo L. One-day behavioral intervention for distressed veterans with migraine: results of a multimethod pilot study. Mil Med. 2018;183(7–8):e184–e192.Google Scholar
  38. 38.
    Wag YC, Huang YP, Want MT, et al. Increased risk of rheumatoid arthritis in patients with migraine: a population-based, propensity score-matched cohort study. Rheumatol Int. 2017;37(2):273–9.CrossRefGoogle Scholar
  39. 39.
    Martin AT, Pinney SM, Xie C, Herrick RL, Bai Y, Buckholz J, et al. Headache disorders may be a risk factor for the development of new onset hypothyroidism. Headache. 2017;57(1):21–30.CrossRefPubMedCentralGoogle Scholar
  40. 40.
    Ekici B, Cebeci AN. The debate on the link between subclinical hypothyroidism and childhood migraine: is initial endocrinological evaluation necessary for children with migraine? Acta Neurol Belg. 2015;115(2):123–7.CrossRefPubMedCentralGoogle Scholar
  41. 41.
    Islam MA, Alam F, Wong KK. Cormorbid association of antiphospholipid antibodies and migraine: a systematic review and meta-analysis. Autoimmun Rev. 2017;16(5):512–22.CrossRefPubMedCentralGoogle Scholar
  42. 42.
    Sacco S, Kurth T. Migraine and the risk of stroke and cardiovascular disease. Curr Cardiol Rep. 2014;16:524.CrossRefPubMedCentralGoogle Scholar
  43. 43.
    Kurth T, Winter AC, Eliassen AH, et al. Migraine and risk of cardiovascular disease in women: prospective cohort study. BMJ. 2016;i2610:353.Google Scholar
  44. 44.
    O’Keeffe ST, Tsapatsaris NP, Beetham WP Jr. Association between Raynaud’s phenomenon and migraine in a random population of hospital employees. J Rheumatol. 1993 Jul;20(7):1187–8.PubMedPubMedCentralGoogle Scholar
  45. 45.
    Lau C, Lin C, Chen W, Wang H, Kao C. Association between migraine and irritable bowel syndrome: a population-based retrospective cohort study. Eur J Neurol. 2014;21:1198–204.CrossRefPubMedCentralGoogle Scholar
  46. 46.
    Faresjo A, Grodzinsky E, Hallert C, Timpka T. Patients with irritable bowel syndrome are more burdened by co-morbidity and worry about serious diseases than healthy controls- eight years follow-up of IBS patients in primary care. BMC Public Health. 2013;13:832.CrossRefPubMedCentralGoogle Scholar
  47. 47.
    van Hemert S, Breedveld AC, Rovers JM, Vermeiden JP, Witteman BJ, Smits MG, et al. Migraine associated with gastrointestinal disorders: review of the literature and clinical implications. Front Neurol. 2014;5:241.PubMedPubMedCentralGoogle Scholar
  48. 48.
    Aydinlar E, Dikmen P, Tiftikci A, Saruc M, Aksu M, Gunsoy H, et al. IgG-based elimination diet in migraine plus irritable bowel syndrome. Headache. 2013;53:514–425.CrossRefPubMedCentralGoogle Scholar
  49. 49.
    Camara-Lemarroy CR, Rodriguez-Gutierrez R, Monreal-Robles R, Marfil-Rivera A. Gastrointestinal disorders associated with migraine: a comprehensive review. World J Gastroenterol. 2016;22:8149–60.CrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Britany Klenofsky
    • 1
  • Anna Pace
    • 2
  • Lauren R. Natbony
    • 2
  • Huma U. Sheikh
    • 1
    • 2
    Email author
  1. 1.Mount Sinai Beth IsraelNew YorkUSA
  2. 2.Icahn School of Medicine at Mount SinaiNew YorkUSA

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