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Complex Regional Pain Syndrome, Current Concepts and Treatment Options

  • Ivan Urits
  • Abra H. Shen
  • Mark R. Jones
  • Omar Viswanath
  • Alan D. KayeEmail author
Other Pain (A Kaye and N Vadivelu, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Other Pain

Abstract

Purpose of Review

Complex regional pain syndrome (CRPS) refers to a chronic pain condition that is characterized by progressively worsening spontaneous regional pain without dermatomal distribution. The symptomatology includes pain out of proportion in time and severity to the inciting event. The purpose of this review is to present the most current information concerning epidemiology, diagnosis, pathophysiology, and therapy for CRPS.

Recent Findings

In recent years, discovery of pathophysiologic mechanisms of CRPS has led to significant strides in the understanding of the disease process.

Summary

Continued elucidation of the underlying pathophysiological mechanisms will allow for the development of more targeted and effective evidence-based therapy protocols. Further large clinical trials are needed to investigate mechanisms and treatment of the disorder.

Keywords

Complex regional pain syndrome CRPS-1 Disproportionate pain Allodynia Hyperalgesia Budapest criteria Spinal cord stimulation 

Notes

Compliance with Ethical Standards

Conflict of Interest

Ivan Urits, Abra H. Shen, Mark R. Jones, and Omar Viswanath declare no conflict of interest. Dr. Kaye is a speaker for Depomed, Inc. and Merck, Inc.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Ivan Urits
    • 1
  • Abra H. Shen
    • 2
  • Mark R. Jones
    • 1
  • Omar Viswanath
    • 1
  • Alan D. Kaye
    • 3
    Email author
  1. 1.Department of Anesthesiology, Critical Care and Pain MedicineHarvard Medical School, Beth Israel Deaconess Medical CenterBostonUSA
  2. 2.Harvard Medical SchoolBostonUSA
  3. 3.Department of AnesthesiologyLousiana State University Health Science CenterNew OrleansUSA

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