Cancer Treatment-Related Neuropathic Pain Syndromes—Epidemiology and Treatment: An Update

  • Ellen M. Lavoie Smith
  • Celia M. Bridges
  • Grace Kanzawa
  • Robert Knoerl
  • James P. KellyIV
  • Anna Berezovsky
  • Charis Woo
Neuropathic Pain (E Eisenberg, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Neuropathic Pain

Abstract

Cancer treatment-related chronic neuropathic pain (NP) is a pervasive and distressing problem that negatively influences function and quality of life for countless cancer survivors. It occurs because of cancer treatment-induced damage to peripheral and central nervous system structures. NP becomes chronic when pain signal transmission persists, eventually sensitizing neurons in the dorsal horn and other pain-processing regions in the central nervous system. Frequently overlooked, NP due to cancer treatment has been understudied. Consequently, only a few pharmacologic interventions have been shown to be effective based on the results of randomized controlled trials. Future research designed to explore pathophysiologic mechanisms and effective mechanism-targeted interventions is sorely needed.

Keywords

Neuropathic pain Chronic pain Cancer treatment-related pain 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Ellen M. Lavoie Smith, Celia M. Bridges, Grace Kanzawa, Robert Knoerl, James P. Kelly IV, Anna Berezovsky, and Charis Woo declare that they have no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Ellen M. Lavoie Smith
    • 1
  • Celia M. Bridges
    • 1
  • Grace Kanzawa
    • 1
  • Robert Knoerl
    • 1
  • James P. KellyIV
    • 2
  • Anna Berezovsky
    • 2
  • Charis Woo
    • 1
  1. 1.University of Michigan School of NursingAnn ArborUSA
  2. 2.University of MichiganAnn ArborUSA

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