Cannabinoids for Neuropathic Pain

Neuropathic Pain (E Eisenberg, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Neuropathic Pain

Abstract

Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects. The endocannabinoid system has been elucidated over the last several years, demonstrating a significant interface with pain homeostasis. Exogenous cannabinoids have been demonstrated to be effective in a range of experimental neuropathic pain models, and there is mounting evidence for therapeutic use in human neuropathic pain conditions. This article reviews the history, pharmacologic development, clinical trials results, and the future potential of nonsmoked, orally bioavailable, nonpsychoactive cannabinoids in the management of neuropathic pain.

Keywords

Cannabinoids Endocannabinoid system Neuropathic pain 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Perry G. Fine and Mark J. Rosenfeld serve on the Board of Directors of ISA Scientific, Inc., a medicinal cannabinoid research and development company.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Pain Research and Management Centers, School of Medicine, Department of AnesthesiologyUniversity of UtahSalt Lake CityUSA
  2. 2.ISA Scientific, Inc.DraperUSA

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