Using Animal Models to Understand Cancer Pain in Humans
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Cancer pain is not a single entity but a complex pain state involving different pain syndromes, with inflammatory, neuropathic, compressive, and ischaemic mechanisms. Current therapeutic regimens are based largely on opioids, although opioid treatment can lead to many side effects. Studies using animal models of cancer pain are aimed at understanding cancer pain and developing novel therapies. The most frequently reported models are of bone cancer pain, predominantly modelling pain associated with tumour growth within bone marrow. Here we summarise recent findings from studies using animal models of cancer pain and discuss the methodological quality of these studies.
KeywordsCancer pain Animal models Neuropathic pain Inflammation Opioid treatment
Compliance with Ethics Guidelines
Conflict of Interest
Dr. Gillian L. Currie, Dr. Emily S. Sena, Dr. Marie T. Fallon, Dr. Malcolm R. Macleod and Dr. Lesley A. Colvin each declare no potential conflicts of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance
- 2.•Currie GL, Delaney A, Bennett MI, Dickenson AH, Egan KJ, Vesterinen HM, et al. Animal models of bone cancer pain: systematic review and meta-analyses. Pain. 2013;154(6):917–26. doi: 10.1016/j.pain.2013.02.033. This systematic review and meta-analysis describing in vivo modelling of bone cancer pain showed for the first time that methodological quality has a significant impact on reported behavioural outcomes in in vivo studies of pain. Blinding and randomisation were associated with smaller observed differences in behavioural outcomes between tumour-bearing and control animals.PubMedCrossRefGoogle Scholar
- 7.•Sikandar S, Dickenson II AH. No need for translation when the same language is spoken. Br J Anaesth. 2013;111(1):3–6. doi: 10.1093/bja/aet210. This editorial explored the reasons for the apparent failure of results from studies using animal models of chronic pain to translate to effective therapies to the clinic.PubMedCrossRefGoogle Scholar
- 8.Muralidharan A, Wyse BD, Smith MT. Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioral, pharmacological, radiological, histological and immunohistochemical methods. Pharmacol Biochem Behav. 2013;106:33–46. doi: 10.1016/j.pbb.2013.02.020.PubMedCrossRefGoogle Scholar
- 18.Hu S, Mao-Ying QL, Wang J, Wang ZF, Mi WL, Wang XW, et al. Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines. J Neuroinflammation. 2012;9:278. doi: 10.1186/1742-2094-9-278.PubMedCentralPubMedCrossRefGoogle Scholar
- 21.Hansen RR, Nasser A, Falk S, Baldvinsson SB, Ohlsson PH, Bahl JM, et al. Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice. Eur J Pharmacol. 2012;688(1–3):27–34. doi: 10.1016/j.ejphar.2012.05.008.PubMedCrossRefGoogle Scholar
- 24.Pevida M, Gonzalez-Rodriguez S, Lastra A, Hidalgo A, Menendez L, Baamonde A. CCL2 released at tumoral level contributes to the hyperalgesia evoked by intratibial inoculation of NCTC 2472 but not B16-F10 cells in mice. Naunyn Schmiedebergs Arch Pharmacol. 2012;385(11):1053–61. doi: 10.1007/s00210-012-0787-2.PubMedCrossRefGoogle Scholar
- 30.Gu X, Mei F, Liu Y, Zhang R, Zhang J, Ma Z. Intrathecal administration of the cannabinoid 2 receptor agonist JWH015 can attenuate cancer pain and decrease mRNA expression of the 2B subunit of N-methyl-D-aspartic acid. Anesth Analg. 2011;113(2):405–11. doi: 10.1213/ANE.0b013e31821d1062.PubMedCrossRefGoogle Scholar
- 35.Nakamura A, Hasegawa M, Minami K, Kanbara T, Tomii T, Nishiyori A, et al. Differential activation of the mu-opioid receptor by oxycodone and morphine in pain-related brain regions in a bone cancer pain model. Br J Pharmacol. 2013;168(2):375–88. doi: 10.1111/j.1476-5381.2012.02139.x.PubMedCentralPubMedCrossRefGoogle Scholar
- 39.Adelstein DJ, Ridge JA, Gillison ML, Chaturvedi AK, D'Souza G, Gravitt PE, et al. Head and neck squamous cell cancer and the human papillomavirus: summary of a National Cancer Institute State of the Science Meeting, November 9–10, 2008, Washington, D.C. Head Neck. 2009;31(11):1393–422.PubMedCrossRefGoogle Scholar
- 41.Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Ashikawa M, et al. Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P and mu-opioid receptors in the spinal cord of mice. Anesthesiology. 2012;117(4):847–56. doi: 10.1097/ALN.0b013e31826a4ac8.PubMedCrossRefGoogle Scholar