The Role of Vitamin D in Pathophysiology and Treatment of Fibromyalgia

  • Carlos A. S. Jesus
  • David Feder
  • Mario F. P. Peres
Fibromyalgia (M Peres, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Fibromyalgia

Abstract

Recent studies showed that most cells have receptors and enzymes responsible for metabolism of vitamin D. Several diseases have been linked to vitamin D deficiency, such as hypertension, diabetes, depression, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and chronic pain syndromes such as fibromyalgia. The association between fibromyalgia and vitamin D deficiency is very controversial in the literature with conflicting studies and methodological problems, which leads to more questions than answers. The purpose of this article is to raise questions about the association of hypovitaminosis D with fibromyalgia considering causal relationships, treatment, and pathophysiological explanations.

Keywords

Fibromyalgia Pain Hypovitaminosis D Vitamin D deficiency Pathophysiology 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Carlos A S Jesus declares that he has no potential conflicts.

David Feder declares that he has no potential conflicts.

Mario F P Peres serves as a Section Editor for Current Pain and Headache Reports.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Carlos A. S. Jesus
    • 1
  • David Feder
    • 2
  • Mario F. P. Peres
    • 1
  1. 1.Department of Neurology and NeurosurgeryUNIFESPSão PauloBrazil
  2. 2.Pharmacology DepartmentFaculdade de Medicina do ABCSanto AndreBrazil

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