Current Pain and Headache Reports

, Volume 16, Issue 5, pp 388–398 | Cite as

Brain Imaging in Fibromyalgia

  • Liliana Lourenço JorgeEmail author
  • Edson AmaroJr.
Fibromyalgia (MFP Peres, Section Editor)


Fibromyalgia is a primary brain disorder or a result of peripheral dysfunctions inducing brain alterations, with underlying mechanisms that partially overlap with other painful conditions. Although there are methodologic variations, neuroimaging studies propose neural correlations to clinical findings of abnormal pain modulation in fibromyalgia. Growing evidences of specific differences of brain activations in resting states and pain-evoked conditions confirm clinical hyperalgesia and impaired inhibitory descending systems, and also demonstrate cognitive-affective influences on painful experiences, leading to augmented pain-processing. Functional data of neural activation abnormalities parallel structural findings of gray matter atrophy, alterations of intrinsic connectivity networks, and variations in metabolites levels along multiple pathways. Data from positron-emission tomography, single-photon-emission-computed tomography, blood-oxygen-level-dependent, voxel-based morphometry, diffusion tensor imaging, default mode network analysis, and spectroscopy enable the understanding of fibromyalgia pathophysiology, and favor the future establishment of more tailored treatments.


Fibromyalgia Magnetic resonance imaging Chronic pain Postsynaptic potential summation Pain measurement Brain mapping Functional neuroimaging Tomography Emission-computed, single-photon Positron-emission tomography 



The authors thank Dr Mario Peres and Dr David Borsook (invitation), and Mara Beloni (proofreading).


No potential conflicts of interest relevant to this article were reported.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Hospital Israelita Albert Einstein and Instituto de Reabilitação “Lucy Montoro”MorumbiBrazil
  2. 2.Instituto do Cérebro, Hospital Israelita Albert EinsteinMorumbiBrazil
  3. 3.Department of RadiologyUniversity of Sao PauloSao PauloBrazil

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