Treatment of Perimenstrual Migraine with Triptans: an Update
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Pure menstrual migraine (PMM) and menstrually related migraine (MRM) are difficult challenges in migraine management. Triptans are a class of highly selective serotonin receptor agonists, which interfere with the pathogenesis of migraine and are effective in relieving the associated neurovegetative symptoms. In recent years triptans have been extensively proposed for the treatment of severe, disabling, and recurrent perimenstrual migraine attacks. This review summarizes the different levels of recommendations for the use of triptans in the treatment of perimenstrual migraine. This review is also intended to offer an updated reasonable guide to physicians treating perimenstrual migraine in daily practice.
KeywordsMenstrual migraine Pure menstrual migraine Perimenstrual migraine Triptans Perimenstrual short-term prevention
B. Casolla: none; L. Lionetto: none; S. Candela: none. Dr. Lidia D’Alonzo has received travel expense compensation from Pfizer. Dr. Andrea Negro has received travel expense compensation from Menarini and Pfizer. Dr. Maurizio Simmaco has received payment for the development of educational presentations from Diatech Pharmacogenomics. Dr. Paolo Martelletti is a member of an advisory board to Allergan, Inc.; has received grants, honoraria, and/or research support from ACRAF, Allergan, and Almirall; has received payment for the development of educational presentations from Allergan, ACRAF Angelini, Almirall, and Guidotti; and has received travel expense compensation from Nevro Corporation, Menarini, and the Lifting The Burden campaign.
Papers of particular interest, published recently, have been highlighted as:•• Of major importance
- 6.•• Sacco S, Ricci S, Degan D, et al. Migraine in women: the role of hormones and their impact on vascular diseases. J Headache Pain 2012;13:177–189. This recent review highlights the importance of hormones in developing mechanisms and worsening risk factors of migraine in women. PubMedCrossRefGoogle Scholar
- 21.Behrman HR, Caldwell BV. Prostaglandins, thromboxanes, and leukotrienes. In: Yen SSC, Jaffe RB, editors. Reproductive endocrinology: physiology, pathophysiology and clinical management. Philadelphia: Saunders; 1986. p. 154–76.Google Scholar
- 24.Yen SSC. Prolactin in human reproduction. In: Yen SSC, Jaffe RB, editors. Reproductive endocrinology, physiology, pathophysiology and clinical management. Philadelphia: Saunders; 1986. p. 237–63.Google Scholar
- 25.Nappi G, Martignoni E. Significance of hormonal changes in primary headache disorders. In: Olesen J, Edvinsson L, editors. Basic mechanisms of headache. New York: Elsevier; 1988. p. 277–98.Google Scholar
- 42.Bartolini M, Giamberardino MA, Lisotto C, et al. Frovatriptan versus almotriptan for acute treatment of menstrual migraine: analysis of a double-blind, randomized, cross-over, multicenter, Italian, comparative study. J Headache Pain. 2012. doi: 10.1007/s10194-012-0455-4.
- 46.Massiou H, Pitei D, Poole P, et al. Efficacy of eletriptan for the treatment of migraine in women with menstrually associated migraine, and in women on contraceptives or hormone replacement therapy: meta-analyses of randomized clinical trials [abstract]. Cephalalgia. 2000;20:435.CrossRefGoogle Scholar