Current Pain and Headache Reports

, Volume 16, Issue 1, pp 73–79 | Cite as

Dependent Behavior in Patients with Medication-Overuse Headache

  • Jong-Ling FuhEmail author
  • Shuu-Jiun Wang
Chronic Daily Headache (S-J Wang, Section editor)


Two thirds of patients with medication-overuse headache (MOH) fulfilled criteria for dependence on acute symptomatic treatments for pain, not exclusive of psychoactive medications, based on the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders. Several questionnaires have been used to assess dependent behavior in patients with MOH. Findings regarding underlying psychological profiles of dependence and MOH are not consistent. Nevertheless, several neuroimaging, genetic, and neurobiological studies support the existence of the common pathophysiological features of dependence and MOH and suggest a link between them. This review highlights recent studies on the relationship between dependence and MOH. This issue is important because it implies a treatment strategy in managing patients with MOH by providing the treatment of dependence.


Medication-overuse headache Substance dependence Migraine Analgesics Chronic daily headache Comorbidity Psychological factors Affective disorders 



This study was supported by grants from the Veterans’ General Hospital University System of Taiwan (VGHUST) Joint Research Program (VGHUST100-G7-1-3 & VGHUST100-G7-1-1).


Dr. Jong-Ling Fuh has served on the advisory boards of Eli Lilly Taiwan, and has received research grants from the Taiwan National Science Council, Taipei-Veterans General Hospital and Eli Lilly. Dr. Shuu-Jiun Wang has served on the advisory boards of Pfizer, Allergan, and Eli Lilly Taiwan; has received speaking honoraria from Taiwan branches of Eli Lilly, Boehringer Ingelheim, and GlaxoSmithKline; and has received research grants from the Taiwan National Science Council and Taipei-Veterans General Hospital.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Neurologythe Neurological Institute, Taipei Veterans General HospitalTaipeiTaiwan
  2. 2.National Yang-Ming University School of MedicineTaipeiTaiwan

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