Current Pain and Headache Reports

, Volume 13, Issue 3, pp 231–236 | Cite as

Newest aspects on the association between migraine and cardiovascular disease: The role of modifying factors

  • Tobias KurthEmail author
  • Markus Schürks


Migraine has been established as a risk factor for ischemic stroke. Further evidence suggests that migraine is also associated with other ischemic vascular events, including myocardial infarction and cardiovascular death. However, these associations appear to be limited to the subgroup of patients with migraine with aura (MA). Moreover, there is increasing evidence that among patients with MA, additional subgroups exist that carry particular increased risk. The association with ischemic stroke is, for example, particularly strong for younger women with MA who smoke and/or use oral contraceptives. Results from recent studies support an even more complex interrelationship characterized by additional modifying effects of other factors on the association between MA and ischemic vascular events. These include vascular risk factors, migraine attack frequency, and genetic variants. In addition, there appear to be differential effects with regard to ischemic stroke and myocardial infarction. These new findings await confirmation in independent patient populations and are currently not sufficient to argue for a change in diagnostic testing or treatment.


Migraine Ischemic Stroke Migraine With Aura Vascular Risk Factor Framingham Risk Score 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Medicine Group, LLC 2009

Authors and Affiliations

  1. 1.INSERM Unit 708, NeuroepidemiologyHôpital de la Pitié-SalpêtrièreParis Cedex 13France

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