Current Pain and Headache Reports

, Volume 12, Issue 3, pp 207–212 | Cite as

Putative mechanisms of the relationship between obesity and migraine progression



Studies suggest that obesity is associated with migraine progression from an episodic into a chronic form. We discuss putative mechanisms to justify this relationship. Several of the inflammatory mediators that are increased in obese individuals are important in migraine pathophysiology, including interleukins and calcitonin gene-related peptide. Both migraine and obesity are prothrombotic states. Substances that are important in metabolic control are nociceptive at certain levels. Hypothalamic dysfunction in the orexin pathways seems to be a risk factor for both conditions. In addition, we discuss the importance of metabolic syndrome and autonomic dysfunction in modulating the obesity/migraine progression relationship.


Obesity Migraine Chronic Migraine Migraine With Aura Chronic Daily Headache 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Medicine Group LLC 2008

Authors and Affiliations

  1. 1.Global Director for Scientific Affairs, NeuroscienceMerck Research LaboratoriesWhite-house StationUSA

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