Current Pain and Headache Reports

, Volume 11, Issue 4, pp 293–296

High-altitude headache

Article

Abstract

High-altitude headache (HAH) is an important public health problem because many of the millions of visitors to locations high above sea level get significant headaches each year. Headache is the most common symptom of acute exposure to high altitude. It may be a manifestation of acute mountain sickness (AMS), as well as of chronic mountain sickness (CMS). This article describes the clinical picture of AMS and CMS. The clinical characteristics of HAH are presented, its pathophysiology is discussed, and the acute and preventive treatment options are reviewed.

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References and Recommended Reading

  1. 1.
    Hackett PH, Roach RC: High-altitude illness. N Engl J Med 2001, 345:107–114.PubMedCrossRefGoogle Scholar
  2. 2.
    Honigman B, Theis MK, Koziol-McLain J, et al.: Acute mountain sickness in a general tourist population at moderate altitudes. Ann Intern Med 1993, 118:587–592.PubMedGoogle Scholar
  3. 3.
    Brundrett G: Sickness at high altitude: a literature review. J R Soc Health 2002, 122:14–20.PubMedGoogle Scholar
  4. 4.
    Rodway GW, Hoffman LA, Sanders MH: High-altitude-related disorders—part I: pathophysiology, differential diagnosis, and treatment. Heart Lung 2003, 32:353–359.PubMedCrossRefGoogle Scholar
  5. 5.
    Silber E, Sonnenberg P, Collier DJ, et al.: Clinical features of headache at altitude: a prospective study. Neurology 2003, 60:1167–1171.PubMedGoogle Scholar
  6. 6.
    Roach RC, Hackett PH: Frontiers of hypoxia research: acute mountain sickness. J Exp Biol 2001, 204:3161–3170.PubMedGoogle Scholar
  7. 7.
    Arregui A, Leon-Velarde F, Cabrera J, et al.: Migraine, polycythemia and chronic mountain sickness. Cephalalgia 1994, 14:339–341.PubMedCrossRefGoogle Scholar
  8. 8.
    Jaillard AS, Mazetti P, Kala E: Prevalence of migraine and headache in a high-altitude town of Peru: a population-based study. Headache 1997, 37:95–101.PubMedCrossRefGoogle Scholar
  9. 9.
    Appenzeller O, Minko T, Qualls C, et al.: Migraine in the Andes and headache at sea level. Cephalalgia 2005, 25:1117–1121.PubMedCrossRefGoogle Scholar
  10. 10.
    Serrano-Duenas M: High altitude headache. A prospective study of its clinical characteristics. Cephalalgia 2005, 25:1110–1116.PubMedGoogle Scholar
  11. 11.
    Headache Classification Subcommittee of the International Headache Society: The International Classification of Headache Disorders: 2nd edition. Cephalalgia 2004, 24(Suppl 1):9–160.Google Scholar
  12. 12.
    Queiroz LP, Barea LM, Blank N: An epidemiological study of headache in Florianopolis, Brazil. Cephalalgia 2006, 26:122–127.PubMedCrossRefGoogle Scholar
  13. 13.
    Lipton RB, Stewart WF, Diamond S, et al.: Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001, 41:646–657.PubMedCrossRefGoogle Scholar
  14. 14.
    Arregui A, Cabrera J, Leon-Velarde F, et al.: High prevalence of migraine in a high-altitude population. Neurology 1991, 41:1668–1669.PubMedGoogle Scholar
  15. 15.
    Hackett PH, Yarnell PR, Hill R, et al.: High-altitude cerebral edema evaluated with magnetic resonance imaging: clinical correlation and pathophysiology. JAMA 1998, 280:1920–1925.PubMedCrossRefGoogle Scholar
  16. 16.
    Sanchez del Rio M, Moskowitz MA: High altitude headache. Lessons from headaches at sea level. Adv Exp Med Biol 1999, 474:145–153.PubMedGoogle Scholar
  17. 17.
    Basu M, Sawhney RC, Kumar S, et al.: Glucocorticoids as prophylaxis against acute mountain sickness. Clin Endocrinol (Oxf) 2002, 57:761–767.CrossRefGoogle Scholar
  18. 18.
    Harris NS, Wenzel RP, Thomas SH: High altitude headache: efficacy of acetaminophen vs. ibuprofen in a randomized, controlled trial. J Emerg Med 2003, 24:383–387.PubMedCrossRefGoogle Scholar
  19. 19.
    Burtscher M, Likar R, Nachbauer W, et al.: Ibuprofen versus sumatriptan for high-altitude headache. Lancet 1995, 346:254–255.PubMedCrossRefGoogle Scholar
  20. 20.
    Rodway GW, Hoffman LA, Sanders MH: High-altitude-related disorders—part II: prevention, special populations, and chronic medical conditions. Heart Lung 2004, 33:3–12.PubMedCrossRefGoogle Scholar
  21. 21.
    Gertsch JH, Basnyat B, Johnson EW, et al.: Randomised, double blind, placebo controlled comparison of ginkgo biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: the Prevention of High Altitude Illness Trial (PHAIT). BMJ 2004, 328:797.PubMedCrossRefGoogle Scholar
  22. 22.
    Chow T, Browne V, Heileson HL, et al.: Ginkgo biloba and acetazolamide prophylaxis for acute mountain sickness: a randomized, placebo-controlled trial. Arch Intern Med 2005, 165:296–301.PubMedCrossRefGoogle Scholar
  23. 23.
    Burtscher M, Likar R, Nachbauer W, Philadelphy M: Aspirin for prophylaxis against headache at high altitudes: randomised, double blind, placebo controlled trial. BMJ 1998, 316:1057–1058.PubMedGoogle Scholar
  24. 24.
    Burtscher M, Likar R, Nachbauer W, et al.: Effects of aspirin during exercise on the incidence of high-altitude headache: a randomized, double-blind, placebo-controlled trial. Headache 2001, 41:542–545.PubMedCrossRefGoogle Scholar

Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  1. 1.Department of NeurologyUniversidade Federal de Santa CatarinaFlorianopolisBrazil

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