The relationship between cytokines and pain/depression: A review and current status
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Cytokines are small protein molecules secreted in response to immune stimuli. Recent research has outlined important roles for proinflammatory cytokines in the cascade of normal physiologic responses to environmental stresses, encompassing so-called sickness behavior that is thought to be an adaptive response to infection and other illnesses. Cytokines are involved in signaling that activates central nervous system glial cells. This activation is part of a poorly understood interaction between immune challenge or injury and host that can lead to the development or facilitation of persistent mood symptoms or pathologic pain. This article reviews evidence that may enhance our understanding of how pathologic symptoms, such as mood disorders and neuropathic pain, may emerge from proinflammatory cytokine activation. Possible conceptualizations of these illnesses and potential treatment implications are explored.
KeywordsNeuropathic Pain Paroxetine DHEA Duloxetine Glial Activation
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References and Recommended Reading
- 1.Horst Ibelgauft’s COPE with Cytokines. Available at http://www.copewithcytokines.de. Accessed October 10, 2006.
- 2.Ransohoff RM, Benveniste EN: Cytokines and the CNS. New York: Taylor & Francis; 2006.Google Scholar
- 17.Delgado PL, Price LH, Miller HL, et al.: Serotonin and the neurobiology of depression. Effects of tryptophan depletion in drug-free depressed patients. Arch Genet Psychol 2004, 51:865–874.Google Scholar
- 21.Demetrashvilli M, Raison CL, Miller AH: Depression in at-risk populations. Cent Nerv Syst News 2002, 4:9–12.Google Scholar
- 31.Myers RR, Wagner R, Sorkin LS: Hyperalgesic actions of cytokines on peripheral nerves. In Cytokines and Pain. Edited by Watkins LR, Maier SF. Basel, Switzerland: Birkhause; 1999:133–158.Google Scholar
- 38.Raison CL, Nemeroff CB: Cancer and depression: prevalence, diagnosis, and treatment. Home Health Consult 2000, 7:34–41.Google Scholar