Current Pain and Headache Reports

, Volume 8, Issue 2, pp 133–139 | Cite as

Cluster headache mimics

  • Dale M. Carter


This article discusses cluster headache and a variety of cluster mimics, with the intention of aiding the practitioner in differentiating between primary cluster headache and secondary forms of cluster. Secondary causes of cluster headache include infections, tumors, vascular abnormalities, and head trauma. In addition, other trigeminal autonomic cephalgias occasionally can be difficult to distinguish from primary cluster headache.


Migraine Cluster Head Sumatriptan Cluster Headache Chronic Cluster Headache 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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References and Recommended Reading

  1. 1.
    Headache Classification Committee of the International Headache Society: Classification and diagnostic criteria for headache disorders, cranial neuralgia, and facial pain. Cephalalgia 1988, 8:1–96.CrossRefGoogle Scholar
  2. 2.
    Russel D, Storstein L: Cluster headache: a computerized analysis of 24 Holter ECG recordings and description of ECG rhythm disturbances. Cephalalgia 1983, 3:83–107.CrossRefGoogle Scholar
  3. 3.
    Nappi G, Micreli G, Cavallini A, et al.: Accompanying symptoms of cluster attacks: their relevance to the diagnostic criteria. Cephalalgia 1992, 3:165–168.CrossRefGoogle Scholar
  4. 4.
    Kudrow L: Cluster headache. In Headache: Clinical, Therapeutic, Conceptual, and Research Aspects. Edited by Blau JN. London: Chapman and Hall; 1987:113.Google Scholar
  5. 5.
    Kudrow L, Kudrow DB: Association of sustained oxyhemoglobin desaturation and onset of cluster headache attacks. Headache 1990, 30:471–480.CrossRefGoogle Scholar
  6. 6.
    Dodick DW, Rogers TD, Goadsby PJ, et al.: Cluster headache. Cephalalgia 2000, 20:787–803.PubMedCrossRefGoogle Scholar
  7. 7.
    Graham JR: Cluster headache. Presented at the International Symposium on Headache. Chicago: 1969.Google Scholar
  8. 8.
    Kudrow L: Cluster headache: diagnosis and management. Headache 1979, 19:142–150.PubMedCrossRefGoogle Scholar
  9. 9.
    Manzoni GC: Male preponderance of cluster headache is progressively decreasing over the years. Headache 1997, 37:588–589.PubMedCrossRefGoogle Scholar
  10. 10.
    Kudrow L: Cluster Headache: Mechanisms and Management. New York: Oxford University Press; 1980.Google Scholar
  11. 11.
    Russell MB: Genetic epidemiology of migraine and cluster headache. Cephalalgia 1997, 17:683–701.PubMedCrossRefGoogle Scholar
  12. 12.
    Kudrow L, Kudrow DB: Inheritance of cluster headache and its possible link to migraine. Headache 1994, 34:400–407.PubMedCrossRefGoogle Scholar
  13. 13.
    Russell MB: Increased familial risk and evidence of genetic factors in migraine. BMJ 1995, 311:541–544.PubMedGoogle Scholar
  14. 14.
    Eadie MJ, Sutherland JM: Migrainous neuralgia. Med J Aust 1966, 1:1053–1057.PubMedGoogle Scholar
  15. 15.
    Couturier EG, Hering R, Steiner TJ: The first report of cluster headache in identical twins. Neurology 1991, 41:761.PubMedGoogle Scholar
  16. 16.
    Roberge C, Bouchard JP, Simard D, et al.: Cluster headache in twins. Neurology 1992, 42:1255–1256.PubMedGoogle Scholar
  17. 17.
    Sjaastad O, Shen JM, Stovner LJ, et al.: Cluster headache in identical twins. Headache 1993, 33:214–217.PubMedCrossRefGoogle Scholar
  18. 18.
    Ekbom K, Greitz T: Carotid angiography in cluster headache. Acta Radiol 1970, 10:177–186.Google Scholar
  19. 19.
    Waldenlind E, Ekbom K, Thorhall J: MR-angiography during spontaneous attacks of cluster headache: a case report. Headache 1993, 33:291–295.PubMedCrossRefGoogle Scholar
  20. 20.
    Moskowitz M: Basic mechanisms in vascular headache. Neurol Clin 1990, 8:801–815.PubMedGoogle Scholar
  21. 21.
    Moskowitz MA: Cluster headache: evidence for a pathophysiologic focus in the superior pericarotid cavernous plexus. Headache 1988, 28:584–586.PubMedCrossRefGoogle Scholar
  22. 22.
    Hardebo JE, Dahlof C: Sumatriptan nasal spray (20 mg/dose) in the acute treatment of cluster headache. Cephalalgia 1998, 18:487–489.PubMedCrossRefGoogle Scholar
  23. 23.
    Sjaastad O, Rinck P: Cluster headache: MRI studies of the cavernous sinus and the base of the brain. Headache 1990, 30:350–351.PubMedCrossRefGoogle Scholar
  24. 24.
    Sianard-Gainko J, Milet J, Ghuysen V, et al.: Increased parasellar activity on gallium SPECT is not specific for active cluster headache. Cephalalgia 1994, 14:132–133.PubMedCrossRefGoogle Scholar
  25. 25.
    Hannerz J, Ericson K, Bergstrand G: A new etiology for visual impairment and chronic headache: the Tolosa Hunt Syndrome may be only one manifestation of venous vasculitis. Cephalalgia 1986, 6:59–63.PubMedCrossRefGoogle Scholar
  26. 26.
    Antonaci F: Chronic paroxysmal hemicrania and hemicrania continua: orbital phlebography and MRI studies. Headache 1994, 34:32–34.PubMedCrossRefGoogle Scholar
  27. 27.
    Hannerz J, Greitz D, Hansson P, et al.: SUNCT may be another manifestation of orbital venous vasculitis. Headache 1992, 32:384–389.PubMedCrossRefGoogle Scholar
  28. 28.
    Kudrow L: Plasma testosterone levels in cluster headache preliminary results. Headache 1976, 16:28–31.PubMedCrossRefGoogle Scholar
  29. 29.
    Leone M, Bussone G: A review of hormonal findings in cluster headache: evidence for hypothalamic involvement. Cephalalgia 1993, 13:309–317. This is a great reference for information on the circadian rhythms of hormones controlled by the hypothalamus in cluster headache.PubMedCrossRefGoogle Scholar
  30. 30.
    Leone M, Lucini V, D’Amico, et al.: Twenty-four hour melatonin and cortisol plasma levels in relation to timing cluster headache. Cephalalgia 1995, 15:224–229.PubMedCrossRefGoogle Scholar
  31. 31.
    Leone M, Lucini V, D’Amico D, et al.: Abnormal 24-hour urinary excretory pattern of 6-sulphatoxymelatonin in both phases of cluster headache. Cephalalgia 1998, 18:664–667.PubMedCrossRefGoogle Scholar
  32. 32.
    May A, Bahra A, Buchel, C, et al.: Hypothalamic activation in cluster headache attacks. Lancet 1998, 352:275–278.PubMedCrossRefGoogle Scholar
  33. 33.
    Weiller C, May A, Limroth V, et al.: Brain stem activation in spontaneous human migraine attacks. Nat Med 1995, 1:658–660.PubMedCrossRefGoogle Scholar
  34. 34.
    May A, Kaube H, Buechel C, et al.: Experimental pain elicited by capsaicin: a PET study. Pain 1998, 74:61–66.PubMedCrossRefGoogle Scholar
  35. 35.
    May A, Ashburner J, Buchel C, et al.: Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med 1999, 5:836–838.PubMedCrossRefGoogle Scholar
  36. 36.
    Leone M, Franzini A, Bussone G: Stereotactic stimulation of posterior hypothalamic grey matter in a patient with intractable cluster headache. N Engl J Med 2001, 345:1428–1429.PubMedCrossRefGoogle Scholar
  37. 37.
    Franzini A, Fenoli P, Leone M, et al.: Stimulation of the posterior hypothalamus for treatment of chronic intractable cluster headaches: first reported series. Neurosurgery Online 2003, 52:1095–1101. Interesting surgical approach to inhibiting cluster headache and links evidence to the hypothalamic generator theory of cluster headache.PubMedGoogle Scholar
  38. 38.
    Moore RY: The fourth C.U. Ariens Kappers lecture: the organization of the human circadian timing systems. Brain Res 1992, 93:99–115.CrossRefGoogle Scholar
  39. 39.
    Groos G, Mason R, Meijer J: Electrical and pharmacological properties of the suprachiasmatic nuclei. Fed Proc 1984, 42:2790–2795.Google Scholar
  40. 40.
    Lambert GA, Bogduk N, Goadsby PJ, et al.: Decreased carotid resistance in cats in response to trigeminal stimulation. J Neurosurg 1984, 61:307–315.PubMedGoogle Scholar
  41. 41.
    Goadsby PJ, Duckworth JW: Low frequency stimulation of the locus coeruleus reduces regional cerebral blood flow in the spinalized cat. Brain Res 1989, 326:213–217.CrossRefGoogle Scholar
  42. 42.
    Goadsby PJ, Edvinsson L: Human in vivo evidence for trigeminovascular activation in cluster headache: neuropeptide changes and effects of acute attacks therapies. Brain 1994, 117:427–434.PubMedCrossRefGoogle Scholar
  43. 43.
    Goadsby PJ, Edvinsson L, Ekman R: Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 1990, 28:183–187.PubMedCrossRefGoogle Scholar
  44. 44.
    Goadsby PJ, Edvinsson L: The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol 1993b, 33:48–56.PubMedCrossRefGoogle Scholar
  45. 45.
    Lee M, Lessell S: Orbital myositis posing as cluster headache. Arch Neurol 2002, 59:635–636.PubMedCrossRefGoogle Scholar
  46. 46.
    Leandri M, Cruccu G, Gottlieb A: Cluster headache-like pain in multiple sclerosis. Cephalalgia 1999, 19:732–734.PubMedCrossRefGoogle Scholar
  47. 47.
    Heidegger S, Mattfeldt T, Rieber A, et al.: Orbito-sphenoidal aspergillus infection mimicking cluster headache: a case report. Cephalalgia 1997, 17:676–679.PubMedCrossRefGoogle Scholar
  48. 48.
    Rosebraugh C, Griebel D, DiPette D: A case report of carotid artery dissection presenting as cluster headache. Am J Med April 1997, 102:418–419.CrossRefGoogle Scholar
  49. 49.
    Leira E, Cruz-Flores S, Leacock R: Sumatriptan can alleviate headaches due to carotid artery dissection. Headache 2001, 41:590–591.PubMedCrossRefGoogle Scholar
  50. 50.
    Silberstein S, Niknam R, Rozen T, et al.: Cluster headache with aura. Neurology 2000, 54:219–221.PubMedGoogle Scholar
  51. 51.
    Cremer P, Heilmagyi M, Goadsby P: Secondary cluster headache responsive to sumatriptan. J Neurol Neurosurg Psychiatry 1995, 59:633–634.PubMedCrossRefGoogle Scholar
  52. 52.
    Porta-Etessam J, Ramos-Carrasco A, Berbel-Garcia A, et al.: Clusterlike headache as first manifestation of a prolactinoma. Headache 2001, 41:723–726.PubMedCrossRefGoogle Scholar
  53. 53.
    Tajti J, Sask, Szok D, et al.: Clusterlike headache as a first sign of brain metastases of lung cancer. Headache 1996, 36:259–260.PubMedCrossRefGoogle Scholar
  54. 54.
    Turkewitz J, Wirth O, Dawson G, et al.: Cluster headache following head injury: a case report and review of the literature. Headache 1992, 32:504–506.PubMedCrossRefGoogle Scholar
  55. 55.
    Evers S, Soros P, Brilla R, et al.: Cluster headache after orbital exenteration. Cephalalgia 1997, 17:680–682.PubMedCrossRefGoogle Scholar
  56. 56.
    Matharu M, Goadsby P: Trigeminal autonomic cephalgias. J Neurol Neurosurg Psychiatry 2002, 72:1119–1127.Google Scholar
  57. 57.
    Newman L, Goadsby P, Lipton R: Cluster and related headaches. Med Clin North Am 2001, 85:997–1016.PubMedCrossRefGoogle Scholar

Copyright information

© Current Science Inc 2004

Authors and Affiliations

  • Dale M. Carter
    • 1
  1. 1.PortlandUSA

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