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Current Pain and Headache Reports

, Volume 7, Issue 2, pp 144–149 | Cite as

Epidemiology of cluster headache

  • Alan G. Finkel
Article

Abstract

Cluster headache is rare, occurring in less than 1% of the population. Studies suggest that, in addition to the pain and associated autonomic disturbances recognized to be characteristic of the syndrome, patients also may experience nausea, photophobia, behavioral agitation, or restlessness. A decreasing male:female ratio also has been noted, perhaps attributable to lifestyle trends adopted by more women that were previously associated with men, such as tobacco use, alcohol consumption, and working outside of the home. The relationship between cluster headache and hormonal events does not appear to be strong. Hormonal influences on the chronic form of cluster headache in women are a subject of investigation. The emerging understanding of the genetics of cluster headache increasingly suggests a genetic component, with familial transmission now recognized to be more common than previously appreciated. Head trauma, coronary artery disease, and migraine appear to be present in more patients with cluster headache than can be explained by chance alone. Ethnic and racial differences in prevalence are less well understood.

Keywords

Migraine Cluster Headache Cavernous Sinus International Headache Society Chronic Cluster Headache 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References and Recommended Reading

  1. 1.
    AdHoc Committee on Classification of Headache. JAMA 1962, 179:717-718.Google Scholar
  2. 2.
    Graham JR: Cluster headache. Headache 1972, 11:175–185.PubMedCrossRefGoogle Scholar
  3. 3.
    Levi R, Edman G, Ekbom K, Waldenlind E: Episodic cluster headache II: high tobacco and alcohol consumption in males. Headache 1992, 32:184–187.PubMedCrossRefGoogle Scholar
  4. 4.
    Ekbom K, Waldenlind E: Cluster headache in women: evidence of hypofertility. Cephalalgia 1981, 1:167–174.PubMedCrossRefGoogle Scholar
  5. 5.
    Graham JR: Some clinical and theoretical aspects of cluster headache. In Migraine and Related Headaches. Edited by Saxena P. Rotterdam: Erasmus Universiteit; 1975:27–40.Google Scholar
  6. 6.
    Kudrow L: Cluster Headache: Mechanisms and Management. New York: Oxford University Press; 1980.Google Scholar
  7. 7.
    Ekbom K: A clinical comparison of cluster headache and migraine. Acta Neurol Scand 1970, 46:1–48.Google Scholar
  8. 8.
    World Federation of Neurology’s Research Group on Migraine and Headache. J Neurol Sci 1969, 9:202.Google Scholar
  9. 9.
    Merskey H, Bond MR, Bonica JJ: Classification of chronic pain. Pain 1986, 3(suppl 3):1–226.Google Scholar
  10. 10.
    Headache Classification Committee of the International Headache Society: Classification and diagnostic criteria for headache disorders, cranial neuralgias, and facial pain. Cephalalgia 1988, 8[suppl 7] 1–96.Google Scholar
  11. 11.
    Ekbom K: Evaluation of clinical criteria for cluster headache with special reference to classification of the International Headache Society. Cephalalgia 1990, 10:195–197.PubMedCrossRefGoogle Scholar
  12. 12.
    Horton BT, MacLean AR, Craig WM: A new syndrome of vascular headache. Mayo Clin Proc 1939, 14:257–260.Google Scholar
  13. 13.
    Ekbom K, Ahlborg B, Schele R: Prevalence of migraine and cluster headache in Swedish men of 18. Headache 1978, 18:9.PubMedCrossRefGoogle Scholar
  14. 14.
    Tonon C, Guttmann S, Volpini M, et al.: Prevalence and incidence of cluster headache in the Republic of San Marino. Neurology 2002, 58:1407–1409. Widely quoted and considered a standard, this study canvasses a fixed population over time to demonstrate the natural history in one unique setting. Generalizing these results are difficult. No other population-based study has attempted its rigorous attention to diagnostic confirmation, although there are few patients.PubMedGoogle Scholar
  15. 15.
    Swanson J, Yanagihara T, Stang P, et al.: Incidence of cluster headache: a population-based study of Olmsted County, Minnesota. Neurology 1994, 44:433–437.PubMedGoogle Scholar
  16. 16.
    Munoz M, Dumas M, Boutros-Toni F, et al.: Prevalence of headache in a representative sample of the population in a French department. Headache 1993, 33:521–523.PubMedCrossRefGoogle Scholar
  17. 17.
    Cheung R: Prevalence of migraine, tension-type headache and other headaches in Hong Kong. Headache 2000, 40:473–479.PubMedCrossRefGoogle Scholar
  18. 18.
    Ekbom K, Svensson D, Traff H, Waldenlind E: Age at onset and sex ratio in cluster headache: observations over three decades. Cephalalgia 2002, 22:94–100. This paper addresses the important topic of gender and cluster phenomenology, combining data with the study from San Marino to confirm the consistency of the diagnosis and the changes that occur in women.PubMedCrossRefGoogle Scholar
  19. 19.
    Sjaastad O, Shen JM, Stovner L, Elasas T: Cluster headache in identical twins. Headache 1993, 33:214–217.PubMedCrossRefGoogle Scholar
  20. 20.
    Kudrow L: Cluster Headache. Mechanisms and Management. Oxford: Oxford University Press; 1980:53–57.Google Scholar
  21. 21.
    Kudrow L, Kudrow D: Inheritance of cluster headache and its possible link to migraine. Headache 1994, 34:400–407.PubMedCrossRefGoogle Scholar
  22. 22.
    Russell M, Andersson P, Thomsen L: Familial occurrence of cluster headache. J Neurol Neurosurg Psychiatry 1995, 58:341–343.PubMedCrossRefGoogle Scholar
  23. 23.
    Russell M, Andersson P, Lennert I: Cluster headache is an inherited disorder in some families. Headache 1996, 36:608–612.PubMedCrossRefGoogle Scholar
  24. 24.
    Leone M, Russell M, Rigatoni A, et al.: Increased familial risk of cluster headache. Neurology 2001, 56:1233–1236.PubMedGoogle Scholar
  25. 25.
    Russell M: Genetic epidemiology of migraine and cluster headache. Cephalalgia 1997, 17:683–701.PubMedCrossRefGoogle Scholar
  26. 26.
    Sjostrand C, Giedratis V, Ekbom K, et al.: CACNA1A gene polymorphisms in cluster headache. Cephalalgia 2001, 21:953–958.PubMedCrossRefGoogle Scholar
  27. 27.
    Haan J, van Vliet J, Kors E, et al.: No involvement of the calcium channel gene in a family with cluster headache. Cephalalgia 2001, 21:959–962.PubMedCrossRefGoogle Scholar
  28. 28.
    Sjostrand C, Waldenlind E, Ekbom K: Follow-up study of 60 patients after an assumed first period of cluster headache. Cephalalgia 2000, 20:653–657. In a rare disorder, incomplete data may confound the epidemiology. From the authors’ wide experiences, these important considerations help to counsel patients about the future of their disease.PubMedCrossRefGoogle Scholar
  29. 29.
    Manzoni G, Terzano M, Bono G, et al.: Cluster headache: clinical findings in 180 patients. Cephalalgia 1983, 3:21–30.PubMedCrossRefGoogle Scholar
  30. 30.
    Bahra A, May A, Goadsby P: Cluster headache: a prospective clinical study with diagnostic implications. Neurology 2002, 58:354–361. Using an interesting combination of support groups and clinic patients, Goadsby’s team draws interesting conclusions about the features of cluster headache, including its migrainous features. Close reading may give the reader a keener sense of the patients they now follow and the ones who may be observed in the future.PubMedGoogle Scholar
  31. 31.
    Horton B: Histaminic cephalalgia. Proc Staff Meet Mayo Clinic 1956, 31:325–333.Google Scholar
  32. 32.
    Manzoni G: Male preponderance of cluster headache is progressively decreasing over the years. Headache 1997, 37:588–589.PubMedCrossRefGoogle Scholar
  33. 33.
    Torelli P, Cologna D, Cademartiri C, Manzoni G: Possible predictive factors in the evolution of episode to chronic cluster headache. Headache 2000, 40:798–808.PubMedCrossRefGoogle Scholar
  34. 34.
    Rozen T, Niknam RM, Schecter AL, et al.: Cluster headache in women: clinical characteristics and comparison with cluster headache in men. J Neurol Neurosurg Psychiatry 2001, 70:613–617. This study highlights the issues of gender and race among clinic samples of patients with cluster headache. The authors have opened up new areas of study in cluster headache, many of which are fraught with historic controversy.PubMedCrossRefGoogle Scholar
  35. 35.
    Kudrow L: Cluster headache. In Headache. Edited by Goadsby P, Silberstein S. Boston: Butterworth-Heinemann; 1997:227–239.Google Scholar
  36. 36.
    Italian Cooperative Study Group on the Epidemiology of Cluster Headache: Case-control study of the epidemiology of cluster headache II: anthropometric data and personality profile. Funct Neurol 2000, 15:215–223. This elegant study is worth reading for its methods and attention to detail. The diagnostic findings of the two experts on the basis of facial characteristics confirm the diagnostic-intuitive sense of seasoned professionals.Google Scholar
  37. 37.
    Afra J, Proitetti A, Schoenen J: Craniometric measures in cluster headache patients. Cephalalgia 1998, 18:143–145.PubMedCrossRefGoogle Scholar
  38. 38.
    Torelli P, Cologno D, Cademartiri C, Manzoni G: Primary and secondary cluster headache: two separate entities? Cephalalgia 2000, 20:826–829.PubMedCrossRefGoogle Scholar
  39. 39.
    Kudrow L: Natural history of cluster headache. Headache 1982, 22:203–206.PubMedCrossRefGoogle Scholar
  40. 40.
    Manzoni G, Micieli G, Granella F, et al.: Cluster headache: course over the years in 189 patients. Cephalalgia 1991, 11:169–174.PubMedCrossRefGoogle Scholar
  41. 41.
    Manzoni G, Cicei G, Granella F: Cluster headache in women: clinical findings and relationship with reproductive life. Cephalalgia 1988, 8:37–44.PubMedCrossRefGoogle Scholar
  42. 42.
    Vingen J, Pareja J, Sovner L: Quantitative evaluation of photo and phonophobia in cluster headache. Cephalalgia 1998, 18:250–256.PubMedCrossRefGoogle Scholar
  43. 43.
    Nicoloci M, Sicuteri F, Poggioni: Hypothalamic modulation of nociception and reproduction in cluster headache II: testosterone-induced increase of sexual activity in males with cluster headache. Cephalalgia 1993, 13:258–260.CrossRefGoogle Scholar

Copyright information

© Current Science Inc 2003

Authors and Affiliations

  • Alan G. Finkel
    • 1
  1. 1.Department of NeurologyUniversity of North Carolina, Chapel HillChapel HillUSA

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