Advertisement

Current Pain and Headache Reports

, Volume 7, Issue 1, pp 39–42 | Cite as

Anticonvulsants for the treatment of neuropathic pain syndromes

  • Miroslav Backonja
Article

Abstract

This article is an evidence-based summary of randomized clinical trials published in peer-reviewed journals regarding the efficacy of anticonvulsants for the treatment of neuropathic pain.

Keywords

Carbamazepine Neuropathic Pain Gabapentin Lamotrigine Diabetic Neuropathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References and Recommended Reading

  1. 1.
    Mitchell SW, Morehouse G, Keen W: Gunshot Wounds and Other Injuries of Nerves edn 1. Philadelphia: JB Lippincott & Co; 1864.Google Scholar
  2. 2.
    Tremont-Lukats IW, Megeff C, Backonja MM: Anticonvulsants for neuropathic pain syndromes: mechanisms of action and place in therapy. Drugs 2001, 60:1029–1052. This is a comprehensive review of randomized clinical and open-label studies.CrossRefGoogle Scholar
  3. 3.
    Wiffen P, McQuay H, Carroll D, et al.: Anticonvulsant drugs for acute and chronic pain. Cochrane Database Syst Rev 2000, 2:CD001133. This is an evolving method of reviewing literature.PubMedGoogle Scholar
  4. 4.
    Sindrup SH, Jensen TS: Efficacy of pharmacologic treatments of neuropathic pain: an update and effect related to mechanism of drug action. Pain 1999, 83:389–400.PubMedCrossRefGoogle Scholar
  5. 5.
    Kingery W: A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndrome. Pain 1997, 73:123–139.PubMedCrossRefGoogle Scholar
  6. 6.
    White HS: Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs. Epilepsia 1999, 40(suppl 5):S2-S10.PubMedCrossRefGoogle Scholar
  7. 7.
    Campbell FG, Graham JG, Zilkha KJ: Clinical trial of carbazepine (tegretol) in trigeminal neuralgia. J Neurol Neurosurg Psychiatry 1966, 29:265–267.PubMedCrossRefGoogle Scholar
  8. 8.
    Killian JM, Fromm GH: Carbamazepine in the treatment of neuralgia. Arch Neurol 1968, 19:129–136.PubMedGoogle Scholar
  9. 9.
    Nicol C: A 4-year, double-blind, randomized study of tegritol in facial pain. Headache 1969, 9:54–57.PubMedCrossRefGoogle Scholar
  10. 10.
    Rockliff BW, Davis EH: Controlled sequential trials of carbamazepine in trigeminal neuralgia. Arch Neurol 1966, 15:129–136.PubMedGoogle Scholar
  11. 11.
    Rull JA, Quibrera R, Gonzalez-Millan H, et al.: Symptomatic treatment of peripheral diabetic neuropathy with carbamazepine (Tegretol): double-blind crossover trial. Diabetologia 1969, 5:215–218.PubMedCrossRefGoogle Scholar
  12. 12.
    Lindstrom P, Lindblom U: The analgesic effect of tocainide in trigeminal neuralgia. Pain 1987, 28:45–50.PubMedCrossRefGoogle Scholar
  13. 13.
    Vilming ST, Lyberg T, Lataste X: Tizanidine in the management of trigeminal neuralgia. Cephalalgia 1986, 6:181–182.PubMedCrossRefGoogle Scholar
  14. 14.
    Gomez-Perez FJ, Choza R, Rios JM, et al.: Nortriptyline-fluphenazine versus carbamazepine in the symptomatic treatment of diabetic neuropathy. Arch Med Res 1996, 27:525–529.PubMedGoogle Scholar
  15. 15.
    Lechin F, van Der DB, Lechin ME, et al.: Pimozide therapy for trigeminal neuralgia. Arch Neurol 1989, 46:960–963.PubMedGoogle Scholar
  16. 16.
    Killian JM, Fromm GH: Carbamazepine in the treatment of neuralgia: use of side effects. Arch Neurol 1968, 19:129–136.PubMedGoogle Scholar
  17. 17.
    Taylor CP, Gee NS, Su TZ, et al.: A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res 1998, 29:233–249.PubMedCrossRefGoogle Scholar
  18. 18.
    Backonja M, Beydoun A, Edwards KR, et al.: Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA 1998, 280:1831–1836.PubMedCrossRefGoogle Scholar
  19. 19.
    Rowbotham M, Harden N, Stacey B, et al.: Gabapentin for the treatment of postherpetic neuralgia: a randomized, controlled trial. JAMA 1998, 280:1837–1842.PubMedCrossRefGoogle Scholar
  20. 20.
    Rice AS, Maton S: Gabapentin in postherpetic neuralgia: a randomized, double-blind, placebo-controlled study. Pain 2001, 94:215–224. This is one of the largest pharmacologic efficacy and safety randomized clinical trials that has set new standards. It is clear that gabapentin is an effective and well tolerated drug for the symptomatic control of neuropathic pain.PubMedCrossRefGoogle Scholar
  21. 21.
    Morello CM, Leckband SG, Stoner CP, et al.: Randomized, double-blind study comparing the efficacy of gabapentin with amitriptyline on diabetic peripheral neuropathy pain. Arch Intern Med 1999, 159:1931–1937.PubMedCrossRefGoogle Scholar
  22. 22.
    Zakrzewska JM, Chaudhry Z, Nurmikko TJ, et al.: Lamotrigine (lamictal) in refractory trigeminal neuralgia: results from a double-blind, placebo-controlled crossover trial. Pain 1997, 73:223–230.PubMedCrossRefGoogle Scholar
  23. 23.
    Simpson DM, Olney R, McArthur JC, et al.: A placebo-controlled trial of lamotrigine for painful HIV-associated neuropathy. Neurology 2000, 54:2115–2119. HIV-associated neuropathy is a pain problem that is difficult to treat, but it is encouraging to see positive studies being performed.PubMedGoogle Scholar
  24. 24.
    Vestergaard K, Andersen G, Gottrup H, et al.: Lamotrigine for central poststroke pain: a randomized controlled trial. Neurology 2001, 56:184–190. One of two studies including a patient population that has been neglected in clinical trials. It is encouraging that single-agent lamotrigine relieves pain in this neuropathic pain disorders.PubMedGoogle Scholar
  25. 25.
    Finnerup NB, Sindrup SH, Bach FW, et al.: Lamotrigine in spinal cord injury pain: a randomized, controlled trial. Pain 2002, 96:375–383. The other study of lamotrigine showing its efficacy in treating spinal cord injury pain.PubMedCrossRefGoogle Scholar
  26. 26.
    McCleane G: 200 mg daily of lamotrigine has no analgesic effect in neuropathic pain: a randomized, double-blind, placebo-controlled trial. Pain 1999, 83:105–107.PubMedCrossRefGoogle Scholar

Copyright information

© Current Science Inc 2003

Authors and Affiliations

  • Miroslav Backonja
    • 1
  1. 1.Department of Neurology H6/570University of Wisconsin HospitalMadisonUSA

Personalised recommendations