Current Review of Pain

, Volume 4, Issue 2, pp 148–157 | Cite as

Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome

  • Laurence A. Bradley
  • Nancy L. McKendree-Smith
  • Graciela S. Alarcón


Individuals with fibromyalgia (FM) and/or chronic fatigue syndrome (CFS) report arthralgias and myalgias. However, only persons with FM alone exhibit abnormal pain responses to mild levels of stimulation, or allodynia. We identify the abnormalities in the neuroendocrine axes that are common to FM and CFS as well as the abnormalities in central neuropeptide levels and functional brain activity that differentiate these disorders. These two sets of factors, respectively, may account for the similiarities and differences in the pain experiences of persons with FM and CFS.


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Copyright information

© Current Science Inc 2000

Authors and Affiliations

  • Laurence A. Bradley
    • 1
  • Nancy L. McKendree-Smith
    • 1
  • Graciela S. Alarcón
    • 1
  1. 1.Division of Clinical Immunology and RheumatologyUniversity of Alabama at Birmingham, School of MedicineBirminghamUSA

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