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The Regulation of Marrow Fat by Vitamin D: Molecular Mechanisms and Clinical Implications

  • Hanel Sadie-Van GijsenEmail author
Bone Marrow and Adipose Tissue (G Duque and B Lecka-Czernik, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Bone Marrow and Adipose Tissue

Abstract

Purpose of Review

To review the available literature regarding a possible relationship between vitamin D and bone marrow adipose tissue (BMAT), and to identify future avenues of research that warrant attention.

Recent Findings

Results from in vivo animal and human studies all support the hypothesis that vitamin D can suppress BMAT expansion. This is achieved by antagonizing adipogenesis in bone marrow stromal cells, through inhibition of PPARγ2 activity and stimulation of pro-osteogenic Wnt signalling. However, our understanding of the functions of BMAT is still evolving, and studies on the role of vitamin D in modulating BMAT function are lacking. In addition, many diseases and chronic conditions are associated with low vitamin D status and low bone mineral density (BMD), but BMAT expansion has not been studied in these patient populations.

Summary

Vitamin D suppresses BMAT expansion, but its role in modulating BMAT function is poorly understood.

Keywords

Vitamin D Bone marrow fat Bone mineral density PPARγ2 Marrow fat unsaturation 

Notes

Compliance with Ethical Standards

Conflict of Interest

Hanel Sadie-Van Gijsen declares no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Medicine and Health SciencesStellenbosch University Tygerberg CampusParowSouth Africa

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