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Current Osteoporosis Reports

, Volume 15, Issue 2, pp 110–119 | Cite as

Parathyroid Hormone and Parathyroid Hormone-Related Protein Analogs in Osteoporosis Therapy

  • Benjamin Z. LederEmail author
Therapeutics and Medical Management (S Jan de Beur and B Clarke, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Therapeutics and Medical Management

Abstract

Purpose of Review

The purpose is to review the efficacy and optimal use of parathyroid hormone and parathyroid hormone-related protein analogs in osteoporosis treatment.

Recent Findings

The parathyroid hormone analog teriparatide, a potent stimulator of bone remodeling, increases hip and spine bone mineral density and reduces the risk of vertebral and non-vertebral fractures in postmenopausal osteoporotic women. The parathyroid hormone-related protein analog, abaloparatide, also reduces fracture incidence but has pharmacological effects that differ from teriparatide, particularly in cortical bone. These analogs provide maximal benefit when their use is followed by a potent antiresorptive medication. Moreover, studies have shown that the combination of teriparatide and the RANK-ligand inhibitor, denosumab, increase bone density and estimated strength more than monotherapy and more than any currently available regimen.

Summary

Parathyroid hormone and parathyroid hormone-related protein analogs, whether as monotherapy, in combination with antiresorptive agents or in sequence with antiresorptive agents, will likely play an expanding role in osteoporosis management.

Keywords

Parathyroid hormone Teriparatide Abaloparatide Osteoporosis Anabolic agents Combination therapy Bone mineral density 

Notes

Compliance with Ethical Standard

Conflict of Interest

Benjamin Leder reports grants and personal fees from Amgen; grants from Lilly, during the conduct of the study; and personal fees from Lilly, outside the submitted work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Harvard Medical School, Endocrine UnitMassachusetts General HospitalBostonUSA

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