Current Osteoporosis Reports

, Volume 14, Issue 2, pp 43–48 | Cite as

Bone and Celiac Disease

  • María Belén ZanchettaEmail author
  • Vanesa Longobardi
  • Julio César Bai
Secondary Causes of Osteoporosis (SJ Warden, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Secondary Causes of Osteoporosis


More than 50 % of untreated patients with celiac disease (CD) have bone loss detected by bone densitometry (dual-energy X-ray absorptiometry:DXA). Moreover, patients with CD are more likely to have osteoporosis and fragility fractures, especially of the distal radius. Although still controversial, we recommend DXA screening in all celiac disease patients, particularly in those with symptomatic CD at diagnosis and in those who present risk factors for fracture such as older age, menopausal status, previous fracture history, and familial hip fracture history. Bone microarchitecture, especially the trabecular network, may be deteriorated, explaining the higher fracture risk in these patients. Adequate calcium and vitamin D supplementation are also recommended to optimize bone recovery, especially during the first years of gluten free diet (GFD). If higher fracture risk persists after 1 or 2 years of GFD, specific osteoactive treatment may be necessary to improve bone health.


Celiac disease Bone disorders Gluten-free diet Bone microarchitecture HRp-QCT Osteoporosis Fractures 



We thank Susana Carballo for editing the English language of the manuscript.

Compliance with Ethical Standards

Conflict of Interest

María Belén Zanchetta, Vanesa Longobardi, and Julio César Bai declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

All studies by authors involving animal and/or human subjects were performed after approval by the appropriate institutional review boards. When required, written informed consent was obtained from all participants.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • María Belén Zanchetta
    • 1
    • 2
    Email author
  • Vanesa Longobardi
    • 1
    • 2
  • Julio César Bai
    • 3
  1. 1.IDIM, Instituto de Diagnóstico e Investigaciones MetabólicasBuenos AiresArgentina
  2. 2.Cátedra de Osteología y Metabolismo MineralUniversidad del SalvadorBuenos AiresArgentina
  3. 3.Sección Intestino Delgado, Departamento de Medicina, Hospital de Gastroenterología ¨Dr. C. Bonorino Udaondo¨ and Cátedra de Gastroenterología Facultad de MedicinaUniversidad del SalvadorBuenos AiresArgentina

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