Current Osteoporosis Reports

, Volume 12, Issue 2, pp 189–193

Atypical Femoral Fractures, Bisphosphonates, and Mechanical Stress

Biomechanics (M Silva and P Zysset, Section Editors)


Atypical fractures are stress fractures occurring in the femoral shaft and closely related to bisphosphonate use. We here discuss their radiographic definition and different putative etiologies, apart from mechanical stress. Long time reduction of skeletal remodeling because of bisphosphonate use is thought to allow time for the bone to deteriorate mechanically, resulting in reduced toughness. However, the risk of atypical fracture diminishes rapidly after cessation of treatment, which suggests more acute effects of bisphosphonate use. Microdamage normally accumulates at areas of high stress. Possibly, ongoing bisphosphonate use reduces the ability to resorb and replace areas of microdamage by targeted remodeling. This could lead to crack propagation beyond a point of no return, ending in macroscopic stress fracture.


Atypical femoral fractures Bisphosphonates Bone remodeling Osteoporosis Bone fragility 


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Clinical and Experimental Medicine, Orthopedics, Faculty of Health ScienceLinköping UniversityLinköpingSweden

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