Current Osteoporosis Reports

, Volume 11, Issue 1, pp 11–20 | Cite as

Prostate Cancer and Osteoporosis

  • Stephen P. Tuck
  • Birgit Hanusch
  • Julie Walker
  • Harish K. Datta
Male Osteoporosis (BL Clarke, Section Editor)


Adenocarcinoma of the prostate is one of the commonest cancers in the world. Due to a combination of earlier detection and better treatments, survival has increased dramatically. Prostate cancer itself is associated with lower bone density and increased fractures. This is compounded by the use of androgen deprivation therapy, which causes dramatic falls in circulating testosterone and estrogen, resulting in rapid falls in bone density, decreased muscle mass, and increased fracture rates. Bisphosphonates have been demonstrated to prevent and reverse this bone loss, but there are no anti-fracture data. Denosumab, a monoclonal antibody to RANKL, has recently been shown to increase bone density and reduce fracture rates. Prostate cancer also commonly metastasizes to bone where it can cause complications such as fracture and pain. Both zoledronic acid and denosumab have been demonstrated to reduce skeletal related events. Comparative studies would suggest that densosumab may have an advantage over zoledronic acid.


Prostate cancer Osteoporosis Fractures Androgen deprivation therapy Treatment 



The authors reported no potential conflicts of interest relevant to this article.


Papers of particular interest, published recently, have been highlighted as: • Of importance•• Of major importance

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Stephen P. Tuck
    • 1
    • 2
  • Birgit Hanusch
    • 2
  • Julie Walker
    • 2
  • Harish K. Datta
    • 1
  1. 1.Musculoskeletal Research Group, Institute of Cellular MedicineNewcastle UniversityNewcastle upon TyneUK
  2. 2.James Cook University HospitalMiddlesbroughUK

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