Current Oncology Reports

, 21:94 | Cite as

How We Treat Recurrent Glioblastoma Today and Current Evidence

  • Caroline Chaul-BarbosaEmail author
  • Daniel Fernandes Marques
Neuro-oncology (Y Umemura, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Neuro-oncology


Purpose of Review

Recurrent glioblastoma (rGBM) has no standard treatment. Despite a better molecular knowledge, few therapies have brought changes in clinical practice so far. Here we will review the current data evaluating the re-radiation, re-resection, bevacizumab, and cytotoxic chemotherapy agents in this setting. We will also discuss the advances of immunotherapy and the possible benefit of this treatment for patients with rGBM.

Recent Findings

Next-generation sequencing is increasingly utilized in the clinical practice of neuro-oncologists, bringing gene mutations as targets for therapies. As in other solid tumors, immunotherapy has been also extensively studied in rGBM, with interesting results in phase I and II trials. The most promising therapies in the horizon are combinations including immune checkpoint inhibitors, virotherapy, vaccines, and monoclonal antibodies.


Although re-radiation, re-resection, bevacizumab, and chemotherapy are still the most widely used therapies for treating rGBM, the clinical benefit from these treatments is still not well established. Preliminary results of studies with immune checkpoint inhibitors were disappointing, but virotherapy emerges as more promising immunotherapy in rGBM, especially in combination with other strategies. In addition to the gain in overall survival, the improvement in the quality of life of these patients is also expected.


Recurrent glioblastoma Re-irradiation Immunotherapy in gliomas Virotherapy 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Caroline Chaul-Barbosa
    • 1
    Email author
  • Daniel Fernandes Marques
    • 2
  1. 1.Sirian-Libanese HospitalSao PauloBrazil
  2. 2.Sirian-Libanese HospitalBrasiliaBrazil

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