Updates on Hematologic Malignancies in the Older Adult: Focus on Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia, and Multiple Myeloma
Purpose of Review
Hematologic malignancies are common and difficult to treat in older adults. In this review, we focus on recent updates in diseases with several novel agents relevant to older adults—acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and multiple myeloma (MM).
In AML, CPX-351 offers a new induction chemotherapy for secondary AML that prolongs survival, and venetoclax and IDH inhibitors are efficacious and well tolerated. In CLL, chemoimmunotherapy is being replaced by monoclonal antibodies and small molecule inhibitors that are more effective and better tolerated. In MM, new immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies have expanded treatment options for older patients.
The introduction of novel agents has dramatically shifted the landscape of therapeutic options for older adults with hematologic malignancies. Clinical trials in older adults are needed to expand treatment options for these patients.
KeywordsOlder adults Geriatric oncology Acute myeloid leukemia Chronic lymphocytic leukemia Multiple myeloma Novel agents
Compliance with Ethical Standards
Conflict of Interest
Sandy W. Wong has received research funding from Janssen, Celgene, and Roche.
Charalambos Andreadis has received research funding from Celgene, GlaxoSmithKline, Novartis, Amgen, and Pharmacyclics; has received compensation from Amgen for service as a consultant and from Celgene, Gilead, Pharmacyclics, and Genentech for service on advisory boards. His spouse is also an employee of Genentech.
Rebecca L. Olin has received research funding (salary support, principal investigator) from Astellas, Daiichi Sankyo, Pfizer, and Genentech, and has received compensation from Jazz Pharmaceuticals and Genentech for service as a consultant.
Li-Wen Huang declares that she has no conflict of interest. She is supported by the National Institute on Aging (T32AG000212).
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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