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Current Oncology Reports

, 21:12 | Cite as

Recent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics

  • Jerry Harb
  • Pen-Jen Lin
  • Jijun HaoEmail author
Evolving Therapies (RM Bukowski, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Evolving Therapies

Abstract

Purpose of Review

Review current understanding of both canonical and non-canonical Wnt signaling in cancer and provide updated knowledge in current clinical trials of Wnt signaling drugs.

Recent Findings

Important roles of both canonical and non-canonical Wnt signaling in cancer have been increasingly recognized. Recent clinical trials of several Wnt-signaling drugs have showed promising outcomes. In addition, some drugs that were originally approved for the treatment of other diseases have been recently found to block Wnt signaling, highlighting their potential to treat Wnt-dependent cancer.

Summary

Dysfunction of Wnt signaling is implicated in cancer, and targeting Wnt signaling represents a useful approach to treat cancer. Current clinical trials of Wnt signaling drugs have showed promising outcomes, and repurposing the previously approved drugs for other diseases to treat Wnt-dependent cancer requires further studies.

Keywords

Signaling Cancer Canonical Non-canonical Clinical trial FDA approved Wnt/β-catenin Wnt/Ca2+ Wnt/PCP Wnt inhibitor β-Catenin 

Notes

Funding Information

This work was supported by start-up funds from Western University of Health Sciences to J.H.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

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Authors and Affiliations

  1. 1.Graduate College of Biomedical SciencesWestern University of Health SciencesPomonaUSA
  2. 2.College of Veterinary MedicineWestern University of Health SciencesPomonaUSA

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