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Current Oncology Reports

, 20:93 | Cite as

The Role of Hypnosis in Cancer Care

  • Linda E. CarlsonEmail author
  • Kirsti Toivonen
  • Michelle Flynn
  • Julie Deleemans
  • Katherine-Anne Piedalue
  • Emma Tolsdorf
  • Utkarsh Subnis
Integrative Care (C Lammersfeld, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Integrative Care

Abstract

Purpose of Review

This paper reviews the current evidence-base for the use of hypnosis as an adjunct treatment for common cancer-related symptoms and side effects, including those experienced during treatment, as well as long-term and late effects. First, a general description and history of medical hypnosis in cancer care is provided, followed by a review of the latest evidence across a range of common symptoms.

Recent Findings

The evidence suggests that hypnosis may help treat symptoms of nausea and vomiting in breast cancer patients, manage pain in a variety of contexts, and also reduce levels of anxiety and overall distress around surgical and medical procedures, both in children and adults. Emerging research shows promise for treating hot flashes in women with breast cancer.

Summary

The research in this area would benefit from assessing populations beyond women with breast cancer, including late-stage disease, using more rigorous study designs, following published reporting guidelines and better describing and standardizing interventions.

Keywords

Hypnosis Cancer Breast cancer Nausea Vomiting Pain Anxiety Depression Quality of life Hot flashes Mind-body therapies Integrative oncology 

Notes

Funding information

Dr. Carlson holds the Enbridge Research Chair in Psychosocial Oncology, co-funded by the Canadian Cancer Society Alberta/NWT Division and the Alberta Cancer Foundation, and a Canadian Institutes of Health Research (CIHR) Strategy for Patient-Oriented Research (SPOR) Innovative Clinical Trials Mentorship Chair which funds the TRACTION (Training in Research and Clinical Trials in Integrative Oncology) program. Dr. Subnis is supported by the Enbridge Research Chair in Psychosocial Oncology. Dr. Subnis, Kirsti Toivonen, Michelle Flynn, and Julie Deelmans are supported in part by the CIHR SPOR TRACTION program. Kirsti Toivonen receives funding from a Canadian Institutes of Health Research Doctoral Award and an Izaak Walton Killam Pre-Doctoral Scholarship. Michelle Flynn receives funding from a Canadian Institutes of Health Research Masters Award.

Compliance with Ethical Standards

Conflict of Interest

Linda E. Carlson, Kirsti Toivonen, Michelle Flynn, Julie Deleemans, Katherine-Anne Piedalue, Emma Tolsdorf, and Utkarsh Subnis declare they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.
    • Hammond DC. A review of the history of hypnosis through the late 19th century. Am J Clin Hypn. 2013;56:174–91.  https://doi.org/10.1080/00029157.2013.826172 Provides a thorough chronological overview of the history of hypnosis, from earliest recorded uses worldwide, to applications in medicine and psychiatry in Europe and America. Includes detailed contributions of several prominent figures in the history of hypnosis.CrossRefPubMedGoogle Scholar
  2. 2.
    Upshaw WN. Hypnosis: medicine’s dirty word. Am J Clin Hypn. 2006;49:113–22.  https://doi.org/10.1080/00029157.2006.10401563.CrossRefPubMedGoogle Scholar
  3. 3.
    APA Div. 30: Society of Psychological Hypnosis. About the Society of Psychological Hypnosis. At: http://www.apadivisions.org/division-30/about/index.aspx. 2018. Accessed July 28, 2108.
  4. 4.
    Peter B. Hypnosis. In: Wright JD, editor. International Encyclopedia of the Social & Behavioral Sciences. Second ed. Oxford: Elsevier; 2015. p. 458–64.CrossRefGoogle Scholar
  5. 5.
    • Montgomery GH, Schnur JB, Kravits K. Hypnosis for cancer care: over 200 years young. CA Cancer J Clin. 2012;63:31–44.  https://doi.org/10.3322/caac.21165 Provides a detailed overview of the applications of hypnosis to various aspects of cancer care, including cancer-prevention behaviours, diagnostic procedures, cancer treatment, and cancer survivorship. CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    • Jensen MP, Adachi T, Tomé-Pires C, Lee J, Osman ZJ, Miró J. Mechanisms of hypnosis: toward the development of a biopsychosocial model. Int J Clin Exp Hypn. 2015;63:34–75.  https://doi.org/10.1080/00207144.2014.961875 Provides a thorough review of the evidence of all biological, psychological, and social factors studied in relation to hypnosis; provides rationale for a preliminary biopsychosocial conceptualization of hypnosis.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Tefikow S, Barth J, Maichrowitz S, Beelmann A, Strauss B, Rosendahl J. Efficacy of hypnosis in adults undergoing surgery or medical procedures: a meta-analysis of randomized controlled trials. Clin Psychol Rev. 2013;33:623–36.  https://doi.org/10.1016/j.cpr.2013.03.005.CrossRefPubMedGoogle Scholar
  8. 8.
    Sliwinski J, Fisher W, Johnson A, Elkins G. Medical hypnosis for pain and psychological distress during burn wound debridement: a critical review. OA Altern Med. 2013;1:5.Google Scholar
  9. 9.
    Landolt AS, Milling LS. The efficacy of hypnosis as an intervention for labor and delivery pain: A comprehensive methodological review. Clin Psychol Rev. 2011;31:1022–31.  https://doi.org/10.1016/j.cpr.2011.06.002.CrossRefPubMedGoogle Scholar
  10. 10.
    Bernardy K, Füber N, Klose P, Häuser W. Efficacy of hypnosis/guided imagery in fibromyalgia syndrome - a systematic review and meta-analysis of controlled trials. BMC Musculoskelet Disord. 2011;12:133.  https://doi.org/10.1186/1471-2474-12-133.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Dillworth T, Jensen MP. The role of suggestions in hypnosis for chronic pain: a review of the literature. Open Pain J. 2010;3:39–51.CrossRefGoogle Scholar
  12. 12.
    Palsson OS. Hypnosis treatment of gastrointestinal disorders: a comprehensive review of the empirical evidence. Am J Clin Hypn. 2015;58:134–58.  https://doi.org/10.1080/00029157.2015.1039114.CrossRefPubMedGoogle Scholar
  13. 13.
    Schaefert R, Klose P, Moser G, Häuser W. Efficacy, tolerability, and safety of hypnosis in adult irritable bowel syndrome: systematic review and meta-analysis. Psychosom Med. 2014;76:389–98.CrossRefGoogle Scholar
  14. 14.
    Byron B. The use of hypnosis in the care of the cancer patient. Cancer. 1954;7:1–14 doi: AID-CNCR2820070103>3.0.CO;2–0.CrossRefGoogle Scholar
  15. 15.
    Canadian Cancer Society. Hypnosis (in Cancer Care). At: http://www.cancer.ca/en/cancer-information/diagnosis-and-treatment/complementary-therapies/hypnosis/?region=on. 2018. Accessed July 28, 2018.
  16. 16.
    van Overbruggen R. Hypnosis—American Cancer Society. At: https://helpforhealth.com/hypnose-coaching-2/hypnosis-american-cancer-society/. 2013. Accessed July 25, 2018.
  17. 17.
    Shankar A, Roy S, Malik A, Julka PK, Rath GK. Prevention of chemotherapy-induced nausea and vomiting in cancer patients. Asian Pac J Cancer Prev. 2015;16:6207–13.CrossRefGoogle Scholar
  18. 18.
    Mustian KM, Devine K, Ryan JL, Janelsins MC, Sprod LK, Peppone LJ, et al. Treatment of nausea and vomiting during chemotherapy. US Oncol Hematol. 2011;7:91–7.PubMedPubMedCentralGoogle Scholar
  19. 19.
    Enqvist B, Björklund C, Engman M, Jakobsson J. Preoperative hypnosis reduces postoperative vomiting after surgery of the breasts. Acta Anaesthesiol Scand. 1997;41:1028–32.  https://doi.org/10.1111/j.1399-6576.1997.tb04831.x.CrossRefPubMedGoogle Scholar
  20. 20.
    Richardson J, Smith JE, McCall G, Richardson A, Pilkington K, Kirsch I. Hypnosis for nausea and vomiting in cancer chemotherapy: a systematic review of the research evidence. Eur J Cancer Care (Engl). 2007;16:402–12.  https://doi.org/10.1111/j.1365-2354.2006.00736.x.CrossRefGoogle Scholar
  21. 21.
    Syrjala KL, Cummings C, Donaldson GW. Hypnosis or cognitive behavioral training for the reduction of pain and nausea during cancer treatment: a controlled clinical trial. Pain. 1992;48:137–46.  https://doi.org/10.1016/0304-3959(92)90049-H.CrossRefPubMedGoogle Scholar
  22. 22.
    • Cramer H, Lauche R, Paul A, Langhorst J, Kümmel S, Dobos GJ. Hypnosis in breast cancer care: a systematic review of randomized controlled trials. Integr Cancer Ther. 2015;14:5–15.  https://doi.org/10.1177/1534735414550035 This review is important as it systematically evaluated all published studies in the area up to the year 2014 across a range of outcomes, using standardized methods of comparison. CrossRefPubMedGoogle Scholar
  23. 23.
    Montgomery GH, Bovbjerg DH, Schnur JB, David D, Goldfarb A, Weltz CR, et al. A randomized clinical trial of a brief hypnosis intervention to control side effects in breast surgery patients. J Natl Cancer Inst. 2007;99:1304–12.  https://doi.org/10.1093/jnci/djm106.CrossRefPubMedGoogle Scholar
  24. 24.
    Montgomery GH, Hallquist MN, Schnur JB, David D, Silverstein JH, Bovbjerg DH. Mediators of a brief hypnosis intervention to control side effects in breast surgery patients: response expectancies and emotional distress. J Consult Clin Psychol. 2010;78:80–8.  https://doi.org/10.1037/a0017392.CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Lee DL, Robinson PD, Sabrina B, Mark H, Carol P, Paul G, et al. Guideline for the prevention and treatment of anticipatory nausea and vomiting due to chemotherapy in pediatric cancer patients. Pediatr Blood Cancer. 2014;61:1506–12.  https://doi.org/10.1002/pbc.25063.CrossRefGoogle Scholar
  26. 26.
    Dupuis LL, Roscoe JA, Olver I, Aapro M, Molassiotis A. 2016 updated MASCC/ESMO consensus recommendations: anticipatory nausea and vomiting in children and adults receiving chemotherapy. Support Care Cancer. 2017;25:317–21.  https://doi.org/10.1007/s00520-016-3330-z.CrossRefPubMedGoogle Scholar
  27. 27.
    Tageja N, Groninger H. Chemotherapy-induced nausea and vomiting: an overview and comparison of three consensus guidelines. Postgrad Med J. 2015;92:34–40.  https://doi.org/10.1136/postgradmedj-2014-132969.CrossRefPubMedGoogle Scholar
  28. 28.
    Roila F, Molassiotis A, Herrstedt J, Aapro M, Gralla RJ, Bruera E, Clark-Snow RA, Dupuis LL, Einhorn LH, Feyer P, Hesketh PJ, Jordan K, Olver I, Rapoport BL, Roscoe J, Ruhlmann JH, Walsh D, Warr D, van der Wetering M. MASCC and ESMO Consensus Guidelines for the Prevention of Chemotherapy and Radiotherapy-Induced Nausea and Vomiting: ESMO Clinical Practice Guidelines. Ann Oncol. 2016; 27 Suppl 5:v119–v133.Google Scholar
  29. 29.
    Berlière M, Roelants F, Watremez C, Docquier MA, Piette N, Lamerant S, et al. The advantages of hypnosis intervention on breast cancer surgery and adjuvant therapy. The Breast. 2018;37:114–8.  https://doi.org/10.1016/j.breast.2017.10.017.CrossRefPubMedGoogle Scholar
  30. 30.
    Green CR, Hart-Johnson T, Loeffler DR. Cancer-related chronic pain. Cancer. 2011;117:1994–2003.  https://doi.org/10.1002/cncr.25761.CrossRefPubMedGoogle Scholar
  31. 31.
    van den Beuken-van Everdingen MH, Marieke HJ, Hochstenbach LMJ, Joosten EAJ, Tjan-Heijnen VCG, Janssen DJA. Update on prevalence of pain in patients with cancer: systematic review and meta-analysis. J Pain Symptom Manag. 2016;51:1090.e9.  https://doi.org/10.1016/j.jpainsymman.2015.12.340.CrossRefGoogle Scholar
  32. 32.
    Eaton LH, Brant JM, McLeod K, Yeh C. Nonpharmacologic pain interventions: a review of evidence-based practices for reducing chronic cancer pain. Clin J Oncol Nurs. 2017;21:A9–79.  https://doi.org/10.1188/17.CJON.S3.54-70.CrossRefGoogle Scholar
  33. 33.
    Jibb LA, Nathan PC, Stevens BJ, Seto E, Cafazzo JA, Stephens N, et al. Psychological and physical interventions for the management of cancer-related pain in pediatric and young adult patients: an integrative review. Oncol Nurs Forum. 2015;42:339–E357.  https://doi.org/10.1188/15.onf.e339-e357.CrossRefGoogle Scholar
  34. 34.
    Kuttner L, Bowman M, Teasdale M. Psychological treatment of distress, pain, and anxiety for young children with cancer. J Dev Behav Pediatr. 1988;9:374-81.  https://doi.org/10.1097/00004703-198812000-00010.CrossRefPubMedGoogle Scholar
  35. 35.
    Néron S, Stephenson R. Effectiveness of hypnotherapy with cancer patients’ trajectory: Emesis, acute pain, and analgesia and anxiolysis in procedures. Int J Clin Exp Hypn. 2007;55:336–54.  https://doi.org/10.1080/00207140701338647.CrossRefPubMedGoogle Scholar
  36. 36.
    Syrjala KL, Jensen MP, Mendoza ME, Yi JC, Fisher HM, Keefe FJ. Psychological and behavioral approaches to cancer pain management. J Clin Oncol. 2014;32:1703–11.  https://doi.org/10.1200/JCO.2013.54.4825.CrossRefPubMedPubMedCentralGoogle Scholar
  37. 37.
    Butler LD, Koopman C, Neri E, Giese-Davis J, Palesh O, Thorne-Yocam K, et al. Effects of supportive-expressive group therapy on pain in women with metastatic breast cancer. Health Psychol. 2009;28:579–87.  https://doi.org/10.1037/a0016124.CrossRefPubMedGoogle Scholar
  38. 38.
    Ebell H. The therapist as a travelling companion to the chronically ill: hypnosis and cancer related symptoms. Contemp Hypn. 2008;25:46–56.  https://doi.org/10.1002/ch.348.CrossRefGoogle Scholar
  39. 39.
    Spiegel D, Bloom JR. Group therapy and hypnosis reduce metastatic breast carcinoma pain. Psychosom Med. 1983;45:333–9.CrossRefGoogle Scholar
  40. 40.
    •• Wortzel J, Spiegel D. Hypnosis in cancer care. Am J Clin Hypn. 2017;60:4–17.  https://doi.org/10.1080/00029157.2017.1290577 In this recent review article by leading researchers in the field of psycho-oncology, the current neurobiology of hypnotizability and hypnosis is reviewed, along with the methods and results of hypnosis interventions for pain control in acute and chronic settings. Furthermore, the areas of the brain affected by hypnosis-based interventions for pain-management are described, which provides the neuroanatomy and physiology of hypnotic analgesia. CrossRefPubMedGoogle Scholar
  41. 41.
    • Mendoza ME, Capafons A, Gralow JR, Syrjala KL, Suárez-Rodríguez JM, Fann JR, et al. Randomized controlled trial of the valencia model of waking hypnosis plus CBT for pain, fatigue, and sleep management in patients with cancer and cancer survivors. Psycho-Oncology. 2017;26:1832–8.  https://doi.org/10.1002/pon.4232 This study used rigorous methodology, i.e. blinded randomized controlled trial, to determine the effects of a hypnosis technique combined with CBT for managing the symptoms of pain, fatigue, and sleep problems in a mixed sample of cancer patients taking treatments and cancer survivors post-treatment. The results showed the beneficial effects of hypnosis relative to an educational intervention controlling for the effects of time, therapist attention, and participation in a clinical trial, with benefits that were maintained for at least 3 months’ post-intervention, and without any adverse effects. CrossRefPubMedGoogle Scholar
  42. 42.
    Erickson MH, Rossi EL. Hypnotherapy. Am J Clin Hypn. 1959;2:3–21.CrossRefGoogle Scholar
  43. 43.
    Gallagher E, Rogers BB, Brant JM. Cancer-related pain assessment: monitoring the effectiveness of interventions. Clin J Oncol Nurs. 2017;21:8–12.  https://doi.org/10.1188/17.CJON.S3.8-12.CrossRefPubMedGoogle Scholar
  44. 44.
    Singh P, Chaturvedi A. Complementary and alternative medicine in cancer pain management: a systematic review. Indian J Palliat Care. 2015;21:105–15.  https://doi.org/10.4103/0973-1075.150202.CrossRefPubMedPubMedCentralGoogle Scholar
  45. 45.
    Subnis UB, Starkweather A, Menzies V. A current review of distraction-based interventions for chronic pain management. Eur J Intern Med. 2016;8:715–22.  https://doi.org/10.1016/j.eujim.2016.08.162.CrossRefGoogle Scholar
  46. 46.
    Carlson LE, Waller A, Groff SL, Janine G-D, Bultz BD. What goes up does not always come down: patterns of distress, physical and psychosocial morbidity in people with cancer over a one year period. Psycho-Oncology. 2013;22:168–76.  https://doi.org/10.1002/pon.2068.CrossRefPubMedGoogle Scholar
  47. 47.
    Michael N, Dominic M, Tamsin F, Morwenna R, Christine C, Stuart L, et al. Effectiveness of nonpharmacological interventions to reduce procedural anxiety in children and adolescents undergoing treatment for cancer: a systematic review and meta-analysis. Psycho-Oncology. 2018;Prepublished Online:1–11;27:1889–99.  https://doi.org/10.1002/pon.4749.CrossRefGoogle Scholar
  48. 48.
    •• Pei-Ying C, Ying-Mei L, Mei-Ling C. The effect of hypnosis on anxiety in patients with cancer: a meta-analysis. Worldviews Evid-Based Nurs. 2017;14:223–36.  https://doi.org/10.1111/wvn.12215 This is a comprehensive meta-analysis evaluating studies that have used hypnosis to treat anxiety among both pediatric and adult cancer patients. They have thoroughly synthesized and evaluated recent literature regarding the topic. CrossRefGoogle Scholar
  49. 49.
    Kellerman J, Zeltzer L, Ellenberg L, Dash J. Adolescents with cancer: hypnosis for the reduction of the acute pain and anxiety associated with medical procedures. J Adolesc Health Care. 1983;4:85–90.  https://doi.org/10.1016/S0197-0070(83)80024-2.CrossRefPubMedGoogle Scholar
  50. 50.
    Liossi C, White P, Hatira P. A randomized clinical trial of a brief hypnosis intervention to control venepuncture-related pain of paediatric cancer patients. Pain®. 2009;142:255–63.  https://doi.org/10.1016/j.pain.2009.01.017.CrossRefGoogle Scholar
  51. 51.
    Landier W, Tse AM. Use of complementary and alternative medical interventions for the management of procedure-related pain, anxiety, and distress in pediatric oncology: an integrative review. J Pediatr Nurs. 2010;25:566–79.  https://doi.org/10.1016/j.pedn.2010.01.009.CrossRefPubMedPubMedCentralGoogle Scholar
  52. 52.
    • Bragard I, Etienne A, Faymonville M, Coucke P, Lifrange E, Schroeder H, et al. A nonrandomized comparison study of self-hypnosis, yoga, and cognitive-behavioral therapy to reduce emotional distress in breast cancer patients. Int J Clin Exp Hypn. 2017;65:189–209.  https://doi.org/10.1080/00207144.2017.1276363 This study conducted a comparison study of self-hypnosis to yoga and CBT, examining effects on distress and patient well-being. It is noteworthy for comparing three active interventions in a pragmatic design, but suffers from lack of randomization and unequal group sizes. CrossRefPubMedGoogle Scholar
  53. 53.
    Potie A, Roelants F, Pospiech A, Momeni M, Watremez C. Hypnosis in the perioperative management of breast cancer surgery: clinical benefits and potential implications. Anesthesiol Res Pract. 2016;2016:1–8.  https://doi.org/10.1155/2016/2942416.CrossRefGoogle Scholar
  54. 54.
    Grégoire C, Bragard I, Jerusalem G, Etienne A, Coucke P, Dupuis G, et al. Group interventions to reduce emotional distress and fatigue in breast cancer patients: a 9-month follow-up pragmatic trial. Br J Cancer. 2017;117:1442–9.  https://doi.org/10.1038/bjc.2017.326.CrossRefPubMedPubMedCentralGoogle Scholar
  55. 55.
    •• Grégoire C, Nicolas H, Bragard I, Delevallez F, Merckaert I, Razavi D, et al. Efficacy of a hypnosis-based intervention to improve well-being during cancer: a comparison between prostate and breast cancer patients. BMC Cancer. 2018;18:677.  https://doi.org/10.1186/s12885-018-4607-z This study demonstrates the importance of 1) standardizing interventions so comparisons can be made across groups (and, beyond this publication, across studies) and 2) testing interventions in multiple groups of patients as there may be heterogeneity in patients’ responses. CrossRefPubMedPubMedCentralGoogle Scholar
  56. 56.
    Tao W, Tao X, Song C. Effects of non-pharmacological supportive care for hot flushes in breast cancer: a meta-analysis. Support Care Cancer. 2017;25:2335–47.  https://doi.org/10.1007/s00520-017-3691-y.CrossRefPubMedGoogle Scholar
  57. 57.
    Elkins G, Fisher W, Johnson A, Marcus J, Dove J, Perfect M, et al. Moderating effect of hypnotizability on hypnosis for hot flashes in breast cancer survivors. Contemp Hypn Integr Ther. 2011;28:187–95.PubMedPubMedCentralGoogle Scholar
  58. 58.
    Savard M, Savard J, Quesnel C, Ivers H. The influence of breast cancer treatment on the occurrence of hot flashes. J Pain Symptom Manag. 2009;37:687–97.  https://doi.org/10.1016/j.jpainsymman.2008.04.010.CrossRefGoogle Scholar
  59. 59.
    MacLaughlan David S, Salzillo S, Bowe P, Scuncio S, Malit B, Raker C, et al. Randomised controlled trial comparing hypnotherapy versus gabapentin for the treatment of hot flashes in breast cancer survivors: a pilot study. BMJ Open. 2013;3:e003138.  https://doi.org/10.1136/bmjopen-2013-003138.CrossRefPubMedPubMedCentralGoogle Scholar
  60. 60.
    Gonzalez BD, Small BJ, Cases MG, Williams NL, Fishman MN, Jacobsen PB, et al. Sleep disturbance in men receiving androgen deprivation therapy for prostate cancer: the role of hot flashes and nocturia. Cancer. 2018;124:499–506.  https://doi.org/10.1002/cncr.31024.CrossRefPubMedGoogle Scholar
  61. 61.
    Montgomery GH, Sucala M, Baum T, Schnur JB. Hypnosis for symptom control in cancer patients at the end-of-life: a systematic review. Int J Clin Exp Hypn. 2017;65:296–307.  https://doi.org/10.1080/00207144.2017.1314728.CrossRefPubMedPubMedCentralGoogle Scholar
  62. 62.
    Häuser W, Hagl M, Schmierer A, Hansen E. The efficacy, safety and applications of medical hypnosis: a systematic review of meta-analyses. Dtsch Arztebl Int. 2016;113:289–96.  https://doi.org/10.3238/arztebl.2016.0289.CrossRefPubMedPubMedCentralGoogle Scholar
  63. 63.
    Elkins G, Jensen MP, Patterson DR. Hypnotherapy for the management of chronic pain. Int J Clin Exp Hypn. 2007;55:275–87.  https://doi.org/10.1080/00207140701338621.CrossRefPubMedPubMedCentralGoogle Scholar
  64. 64.
    Moher D, Hopewell S, Schulz KF, Montori V, Gøtzsche PC, Devereaux PJ, et al. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. Int J Surg. 2012;10:28–55.  https://doi.org/10.1016/j.ijsu.2011.10.001.CrossRefPubMedGoogle Scholar
  65. 65.
    Montgomery GH, David D, Kangas M, Green S, Sucala M, Bovbjerg DH, et al. Randomized controlled trial of a cognitive-behavioral therapy plus hypnosis intervention to control fatigue in patients undergoing radiotherapy for breast cancer. J Clin Oncol. 2014;32:557–63.  https://doi.org/10.1200/JCO.2013.49.3437.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Linda E. Carlson
    • 1
  • Kirsti Toivonen
    • 2
  • Michelle Flynn
    • 2
  • Julie Deleemans
    • 1
  • Katherine-Anne Piedalue
    • 1
  • Emma Tolsdorf
    • 2
  • Utkarsh Subnis
    • 1
  1. 1.Department of Oncology, Cumming School of Medicine, Psychosocial ResourcesUniversity of CalgaryCalgaryCanada
  2. 2.Department of PsychologyUniversity of CalgaryCalgaryCanada

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