Current Concepts in the Treatment of Resectable Pancreatic Cancer
Purpose of Review
The diagnosis of pancreatic cancer carries with it a high mortality rate. Despite advances in the field, this has remained relatively unchanged over the last few decades. Current options for the treatment of resectable pancreatic ductal adenocarcinoma will be reviewed here in conjunction with the historical data that support them. We will focus on updates in treatment guidelines and ongoing clinical trials of interest.
For localized disease, standard of care includes resection followed by adjuvant chemotherapy ± chemoradiation. Recently, a report was published supporting the use of doublet therapy with gemcitabine and capecitabine (as opposed to gemcitabine monotherapy), which prompted a practice-changing update to major treatment guidelines. Multiple trials using neoadjuvant treatment, novel therapies, and different forms of radiation are ongoing.
Although pancreatic cancer is an active area of research, outcomes remain dismal. Clinical trials will need to be more robust and innovative to drastically improve survival statistics.
KeywordsPancreatic adenocarcinoma Localized Resectable Chemoradiation
Compliance with Ethical Standards
Conflict of Interest
Marc T. Roth declares that he has no conflict of interest.
Jordan D. Berlin has received compensation from Celgene, Genentech/Roche, AbbVie, Erytech, Armo, Rafael, EMD Serono/Merck KGA, Aduro, Gritstone, Vertex, BelGene, and AstraZeneca for participation on advisory boards, and has also received compensation from Celgene for participation on a steering committee and the APACT trial; has received non-financial support from Symphogen and Karyopharm for participation on advisory boards; and has participated in clinical trials supported by Incyte, EMD Serono/Merck KGA, Genentech, Taiho, AbbVie, FivePrime, Loxo, Symphogen, and Calithera.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance
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