Current Oncology Reports

, 19:74 | Cite as

Double-Hit Large B Cell Lymphoma

  • Yousef Khelfa
  • Yehuda Lebowicz
  • Muhammad Omer Jamil
Lymphomas (MR Smith, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Lymphomas


Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL), accounting for approximately 25% of NHL cases. It is a heterogeneous group of diseases. BCL2, BCL6, and MYC are the most frequent mutated genes in DLBCL. Double-hit lymphoma (DHL) is an aggressive form of DLBCL with an unmet treatment need, in which MYC rearrangement is present with either BCL2 or BCL6 rearrangement. Patients typically present with a rapidly growing mass with B symptoms. DHL has been linked to very poor outcomes when treated with RCHOP chemotherapy. Dual-expressor lymphoma is a form of DLBCL with overexpression of MYC and BCL2/BCL6. There is a paucity of prospective trials evaluating the treatment of DHL. Retrospective series suggest that more aggressive treatment regimens such as DA-EPOCH and hyper CVAD may be more efficacious. However, there remains a lack of consensus regarding optimal treatment for DHL. Further clinical trials, including novel agents, are needed for improvement in outcomes.


Double-hit lymphoma DLBCL MYC BCL2 BCL6 


Compliance with Ethical Standards

Conflict of Interest

Yousef Khelfa, Yehuda Lebowicz, and Muhammad Omer Jamil declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Yousef Khelfa
    • 1
  • Yehuda Lebowicz
    • 1
  • Muhammad Omer Jamil
    • 1
  1. 1.Division of Hematology and Oncology, Department of Internal MedicineMarshall University School of Medicine-Edwards Comprehensive Cancer CenterHuntingtonUSA

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