Current Oncology Reports

, 18:7 | Cite as

Octreotide and Lanreotide in Gastroenteropancreatic Neuroendocrine Tumors

  • Venkata K. Pokuri
  • Mei Ka Fong
  • Renuka Iyer
Gastrointestinal Cancers (J Meyer, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Gastrointestinal Cancers


Neuroendocrine tumors are heterogeneous, rare malignancies that arise most commonly in the gastrointestinal tract and pancreas. They often secrete vasoactive substances resulting in carcinoid syndrome and the tumor cells exclusively express somatostatin receptors. Octreotide and lanreotide are the two synthetic somatostatin analogs used for the control of carcinoid symptoms and tumor progression in advanced inoperable disease. Recent pivotal trials (PROMID and CLARINET studies) established their antitumor activity. We discuss the available data to support their use as symptom controlling and antiproliferative agents. This article also reviews the guidelines (National Comprehensive Cancer Network and North American Neuro Endocrine Tumor Society), cost-analysis (suggesting the cost-effectiveness of lanreotide autogel compared to higher doses of octreotide long acting release formulation in refractory patients), and future directions of somatostatin analogs in the management of patients refractory to conventional doses of octreotide and lanreotide.


Octreotide Lanreotide Synthetic Somatostatin Gastroenteropancreatic Neuroendocrine tumors Cost-analysis 


Compliance with Ethical Standards

Conflict of Interest

Venkata K. Pokuri declares that he has no conflict of interest. Mei Ka Fong participated in the advisory panel for lanreotide (Ipsen Pharmaceuticals) without financial compensation. Renuka Iyer has received compensation from Ipsen Pharmaceuticals for service as a consultant and has also received nonfinancial support from Ipsen for the review of manuscript content.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Medical OncologyRoswell Park Cancer InstituteBuffaloUSA
  2. 2.Department of Pharmacy, Carolinas Healthcare SystemLevine Cancer InstituteCharlotteUSA

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